Scientist - Biotransformation
- Employer
- Amgen
- Location
- Cambridge, MA, US
- Start date
- Jul 18, 2019
View more
- Discipline
- Science/R&D, Biotechnology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Genetown, Best Places to Work
Job Details
In this role you will contribute to Amgen's diverse discovery and development portfolio of therapeutic modalities with a focus on small molecule metabolite identification and elucidation of metabolic pathways. You will work directly with other PKDM stakeholders at multiple Amgen research sites (Cambridge, MA, San Francisco and Thousand Oaks, CA) to influence drug discovery direction including interpretation and communication of the impact of your results on drug safety, chemistry strategy, and clinical pharmacology planning to advance the best therapeutic candidates. In addition, this position will make meaningful and innovative contributions to the fundamental understanding of the biological factors that affect the metabolism and clearance of small molecules as well as contribute to regulatory filing activities.
In this position the core responsibilities are to:
Identify drug metabolites using LC-MSMS and other analytical methodologies (sometimes requiring the use of radio-labelled materials)
Plan, design, and conduct in vitro studies and in vivo sample analysis; analyze, interpret, integrate and communicate study results
Work with project team representatives to design fit-for-purpose metabolite identification studies to achieve an appropriate level of understanding of the disposition of our molecules at various program stages to best meet therapeutic and safety objectives
Devise, articulate, and implement strategies for improvement of the clearance and safety properties for candidate molecules
Implement new techniques, improved processes and evaluate new instrumentation
In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the metabolism of small molecule biotherapeutics including mechanistic studies. The role also allows the individual to write scientific reports, author scientific papers and present at scientific meetings where appropriate. A collaborative and highly capable scientific cross-site community at Amgen is available to support these efforts.
Basic Qualifications
Doctorate degree
OR
Master's degree and 4 years of scientific experience
OR
Bachelor's degree and 6 years of scientific experience
Preferred Qualifications
Master's Degree in a pharmaceutical science, chemistry or equivalent field of study
7+ years of drug discovery and/or development experience
Experience with HRMS and Thermo Orbitrap platform including experience with metabolite ID software (i.e. MassMetaSite, Webmetabase, Compound Discoverer, etc)
Experience planning/performing in vivo radiolabeled ADME studies including sample analysis, metID and report writing
Knowledge/expertise of operating and interpreting 1D/2D NMR data of isolated metabolites
Critical thinking and demonstrated ability to communicate with team members across broad disciplines
Effective oral and written communication skills
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
Company
We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.
We live the mission.
We win together.
We thrive on continual challenge.
Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.
At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.
Connect with us to explore how you can Win, Live, and Thrive at Amgen.
- Website
- http://careers.amgen.com/
- Phone
- 805-447-1000
- Location
-
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks
California
91320-1799
United States
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