Associate Manager, Founder & Special Populations Genetics
- Employer
- Regeneron Pharmaceuticals, Inc.
- Location
- Tarrytown, NY, United States
- Start date
- Jul 17, 2019
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- Discipline
- Science/R&D, Genetics
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
Summary
The overall goals of this position are to conduct analyses in founder and other unique populations, interpret genetic data in order to obtain a deeper understanding of human biology, bioinformatically support analysis and identification of novel targets, and seek indications for drug programs. The successful candidate will work as part of the Founder & Special Populations team as well collaborate with the RGC Analytical Genetics and Therapeutic Area Genetics teams to provide genetic, informatics, and biological support for genetics studies of founder and special populations. The successful candidate will: characterize the allelic architecture of many founder populations, provide bioinformatics support for family-based analyses, identify genes of potential interest through genotype-phenotype associations & other genetic approaches, harness internal & external data sources to better understand novel genetic findings, work with the Analytical Genetics group to seek validation of associations in other RGC population resources, and work with the Translational Genetics & Functional Modeling groups to glean deeper insights into mechanisms & biology.
Responsibilities
• Ability to work collaboratively as a member of the Founder & Special Populations team, with other Regeneron teams, and with external collaborators
• Manage multiple projects simultaneously and complete analyses in a timely & reliable manner
• Catalog and interpret results of allelic architecture analyses in various founder populations to glean novel insights into human biology and develop follow-up strategies
• Interpret results of genotype:phenotype association analyses from whole exome sequencing and genotyping studies
• Apply biological insights, internal and external data sets, published literature, and other resources to prioritize genetic discoveries in founder and other unique populations for functional follow-up
• Provide bioinformatics support for the Mendelian collaborations
• Work with Analytical Genetics and Therapeutic Area Genetics teams to validate potentially interesting findings in founder and other special populations by extending the analyses to other RGC study populations (ex. Geisinger DiscovEHR, UK Biobank)
• Work with Functional Modeling, Therapeutic Focus Area, and Early Clinical Development teams to nominate, design call-back studies, and functional experiments to follow-up on interesting hits
• Summarize and communicate study findings to the Founder and Special Populations team, leadership, and internal and external collaborators
• Survey the literature and attend conferences to incorporate discoveries and findings from the broader genetics community into study opportunities and considerations internally
Requirements
• This position requires a PhD with 2+ years of experience with a strong background in human disease and/or applied population genetics
• Some experience analyzing and interpreting whole exome sequencing and genotyping studies (ex. variant level QC, statistical association analysis, and interpretation of association signals in complex disease)
• Some experience with standard statistical approaches and tools (ex. regression, linear mixed models, PLINK, R) and some programming experience (ex. Linux, Python)
• Ability to summarize data and results to identify patterns, signals, and issues
• An understanding of biology to integrate and leverage diverse datasets to identify interesting variants, genes, and genotype-phenotype associations
• Experience with molecular characterization and functional studies geared towards elucidating gene functions and the mechanistic basis for genetic associations is a plus
This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.
To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.
Company
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
Stock Symbol: REGN
Stock Exchange: NASDAQ
- Website
- https://www.regeneron.com/
- Phone
- 914-847-7000
- Location
-
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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