Senior Research Associate
PACT Pharma is an exciting new company with laboratories in the San Francisco Bay Area. PACT is developing personalized adoptive T cell therapies for the eradication of solid tumors. The identification of neo-epitopes that serve as private mutations for each patient’s cancer creates a unique opportunity to engineer autologous T cells that target and kill tumors expressing these neo-antigens. PACT utilizes technology licensed from the laboratories of Drs. Heath and Baltimore (Caltech) to identify T cells that recognize the neo-epitope. The unique T-cell receptor (TCR) sequences obtained from these neoepitope-reactive cells are then engineered into T cells from the patient’s own blood to produce PACT’s therapeutic product: a tsunami of fresh, active T cells that, following infusion into the patient, recognize and attack each patient’s cancer cells.
We are located in the San Francisco bay area, in the heart of the world’s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants. PACT Pharma is an ambitious cutting-edge undertaking - we fully anticipate our company to become the world’s leader in personalized adoptive T cell therapies for cancer and therefore key to the future of cancer treatment. These positions currently being recruited for our site in Hayward, CA, but we will be relocating to a new site by years ends.
Research Associate/Sr. RA – Gene Editing
The ideal candidate should be experienced the latest molecular cloning and sequencing techniques for the generation and analysis of transgenic T cells. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment and will communicate results to and coordinate efforts with a larger cross-disciplinary team of immunologists, biologists, engineers and bio-informaticians.
- The candidate will be performing experiments to validate and improve the technology for gene editing (knock-in and knock-out) of endogenous and neoE TCRs, and analyzing the resulting data.
- She/he must be able to communicate clearly and concisely, both verbally and in the form of written reports. The incumbent will aid in drafting protocols, and provide data for regulatory documentation to support clinical development.
- The ideal candidate will hold a Bachelor’s degree with 4+ years’ experience, a Master’s degree with 3+ years’ experience with career focus in cell or molecular biology, biochemistry, or molecular genetics.
- Industry experience is preferred.
- The candidate must have hands on experience with nucleic acid purification and use, including primer design, PCR and standard cloning.
- The candidate should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.
An incumbent with experience in the following areas is a plus:
- Experience with liquid handlers/automation equipment
- Experience with informatics, data management, or programming
- Mammalian cell culture and transfection, ideally primary human T cells
- High-throughput sequencing sample preparation and analysis
- Site-specific nucleases (e.g. CRISPR and TALENs) and associated cellular and molecular analysis
- qPCR and/or ddPCR assay design and optimization
- Flow cytometry or FACS