Senior Scientist, Translational Biology (Immunology)

Senior Scientist, Translational Biology (Immunology)

Position Description:

Arcturus Therapeutics is seeking an innovative and highly motivated Immunologist to join our Translational Biology team. Our successful candidate will help build a new class of immune-therapy products based on Arcturus’s proprietary Lipid Nano Particle (LNP) nucleic acid delivery platform and must have strong expertise in immunology and effector cell biology. 

In this role, you will be responsible for leading oncology and immunotherapy projects and identify and interrogate immunomodulatory target pathways using cutting-edge technologies and novel approaches to enrich our company pipeline. You will be responsible for supporting existing immunology-based programs including cancer vaccines and immunotherapy targeted projects.

Our successful candidate will thrive in a proactive, fast-paced ‘can-do’ culture and enjoy collaborating across the full range of development activities and project teams for the ground-breaking, mRNA-based new drug candidates targeting rare disease.  Our candidate should have extensive laboratory research experience and a desire to continue in a laboratory-focused role with a high level of experimental vigor and quality. Prior experience with rodent tumor immunotherapy models, nucleic acid vaccine development, cancer immunology and immunotherapy is strongly preferred.
 

Candidate Qualifications

  • PhD with 10+ years’ experience with an emphasis on target ID and validation in cancer cell biology and immunology
  • Expertise in current technology practices in cancer biology and immunology is required.
  • Experience with in vivo rodent cancer and immunotherapy models with demonstrated proficiency in immunological assays to assess effector cell function is required.
  • Experience in cancer target and immunotherapy drug discovery and development is preferred
  • Develop and conduct immunological and cellular bioassays to support development of clinical candidates.
  • Demonstrated experience in T-cell biology, innate immunity, and a deep understanding of the host immune response against cancer.
  • In-depth knowledge of setting up T-cell activation assays, manipulating dendritic cells and B-cells to present antigens using ex vivo derived immune cells or tumor-infiltrated lymphocytes.
  • Ability to independently design experiments, make detailed observations, analyze data, interpret results and deliver timely results is required.
  • Excellent presentation and oral and written communication skills is required.
  • Proven ability to prepare precise technical summaries and protocols and maintenance of appropriate documentation is required.
  • Previous experience is drug discovery is preferred.
  • Ability to prioritize and work in a fast-paced and diverse environment is required.
  • Strong sense of urgency, initiative, ethics/integrity and innovation is required.

About Us:

Founded in 2013 and based in San Diego, Arcturus Therapeutics Inc. is a publicly traded RNA medicines company. We are developing a portfolio of RNA therapeutics for treatment of diseases with high unmet medical needs. Our team has extensive experience in the discovery and development of RNA medicines, as well as design and utilization of lipid-mediated drug delivery systems. This combination of in-house expertise, innovative spirit, and passion for what we do, uniquely positions us to catalyze the next generation of RNA medicines. Arcturus’ commitment to the development of novel RNA therapeutics has led to partnerships with Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, Ultragenyx Pharmaceutical, Inc., Takeda Pharmaceutical Company Limited, and the Cystic Fibrosis Foundation.

Arcturus is committed to equal opportunity and complies with all applicable national, state and local laws governing nondiscrimination in employment. Arcturus is an eVerify employer.