Research Scientist

Responsibilities

• Design and perform proof-of-mechanism as well as proof-of-concept gene editing studies.
• Hands-on execution of in vitro, ex vivo, and in vivo assays to analyze gene editing of development candidates.
• Perform cell biology, molecular biology, and biochemistry analyses.
• Analyze, interpret, and present experimental data.
• Collaborate with colleagues to ensure timeline adherence and project alignment to meet group and company goals.
• Support external and internal projects via team meetings, presentations, and reports.
• Attention to detail and ability to operate independently.
• Excellent communication and record keeping   skills.

Essential Qualifications

• A PhD degree, or equivalent, with 3-5 years of post-doctoral training or industrial experience.
• Strong background in mammalian gene therapy/editing, RNA biology, DNA repair or related fields.
• Hands-on experience with a broad range of cell and molecular biology techniques.
• Experienced with mammalian cell culture (primary cells and cell lines), transient transfections, standard molecular cloning techniques, and cell-based assays.
• Ability to multitask and readily adapt to change.

Preferred Qualifications

• Familiarity with the field of hematopoiesis and hematological diseases.
• Experience manipulating primary human hematopoietic cells.
• Experience with gene-editing (CRISPR/Cas9, ZFNs, TALENs) and DNA/RNA/protein delivery.
• Knowledge in DNA repair mechanisms and pathways.
• Broad conceptual expertise with genomics technologies and hands-on expertise with assays including microarray analyses, digital PCR and QPCR, and next-gen sequencing.
• Experience in FACS, Luminex multiplex assays, and IHC/ICC/IF.