Research Scientist

Location
94080, South San Francisco
Salary
$130-145K
Posted
Jul 11, 2019
Required Education
Doctorate/PHD/MD
Position Type
Full time

Responsibilities

  • Design and perform proof-of-mechanism as well as proof-of-concept gene editing studies.
  • Hands-on execution of in vitro, ex vivo, and in vivo assays to analyze gene editing of development candidates.
  • Perform cell biology, molecular biology, and biochemistry analyses.
  • Analyze, interpret, and present experimental data.
  • Collaborate with colleagues to ensure timeline adherence and project alignment to meet group and company goals.
  • Support external and internal projects via team meetings, presentations, and reports.
  • Attention to detail and ability to operate independently.
  • Excellent communication and record keeping   skills.

 

Essential Qualifications

  • A PhD degree, or equivalent, with 3-5 years of post-doctoral training or industrial experience.
  • Strong background in mammalian gene therapy/editing, RNA biology, DNA repair or related fields.
  • Hands-on experience with a broad range of cell and molecular biology techniques.
  • Experienced with mammalian cell culture (primary cells and cell lines), transient transfections, standard molecular cloning techniques, and cell-based assays.
  • Ability to multitask and readily adapt to change.

 

Preferred Qualifications

  • Familiarity with the field of hematopoiesis and hematological diseases.
  • Experience manipulating primary human hematopoietic cells.
  • Experience with gene-editing (CRISPR/Cas9, ZFNs, TALENs) and DNA/RNA/protein delivery.
  • Knowledge in DNA repair mechanisms and pathways.
  • Broad conceptual expertise with genomics technologies and hands-on expertise with assays including microarray analyses, digital PCR and QPCR, and next-gen sequencing.
  • Experience in FACS, Luminex multiplex assays, and IHC/ICC/IF.