Head of DMPK

Location
San Francisco, CA, United States
Posted
Jul 10, 2019
Ref
480
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time
HEAD of DMPK

Position Summary:

GBT is seeking an exceptional scientist and leader to head our Drug Metabolism and Pharmacokinetics (DMPK) department. The successful candidate will develop scientific strategies, lead and mentor a team, and build partnerships cross-functionally to advance GBT's programs. You will be part of an exceptional research team and help advance discovery and development of groundbreaking therapies for serious unmet medical needs.

Essential Duties and Responsibilities:
  • Leadership in preclinical and early clinical studies, including but not limited to in vitro and in vivo ADME assays, PK/TK support, M&S
  • Represent the DMPK function in cross functional project teams and provide critical feedback to project teams from a DMPK perspective
  • Manage collaborations with CRO/CMOs for outsourcing activities
  • Ensure reporting timelines for all DMPK related reports. Expected to review, edit, and offer critical feedback on reports generated by CROs
  • Develop and execute scientific strategies to address ADME challenges on discovery and development programs
  • Build and maintain strong collaborative partnerships with Chemistry, Biology, Preclinical Safety, Clinical Pharmacology, CMC and other R&D disciplines to advance GBT programs through discovery and development
  • Implement creative DMPK technologies and approaches to enhance scientific impact and/or efficiencies
  • Ensure completion of necessary DMPK regulatory documentation and reports to support drug development including Investigator Brochures, INDs (or equivalent), and marketing applications
  • Hire, develop, mentor, manage and retain key talent to maintain a high-performing team
  • Participate in assessment of business development opportunities

Qualifications:
  • Requires a PhD in pharmacokinetics, pharmacy, pharmaceutical sciences, or related discipline with relevant industrial experience
  • Minimum of 10+ years industrial experience with a demonstrated track record advancing both large and small molecule therapeutics from discovery through registration
  • Extensive team leadership and people management experience in cross functional team setting
  • Expert knowledge of scientific principles and concepts
  • Has established a reputation as a leader in the field with sustained performance and accomplishment
  • PhD or equivalent, with >10 years of experience working in a managerial/leadership or a senior scientific role as part of a multifunctional DMPK group in a pharmaceutical company
  • Deep understanding of the drug discovery and development process and cross-functional dependencies
  • Deep scientific and strategic expertise in various components of predictive and translational DMPK science such as in vitro and in vivo ADME, mass spectrometry and bioanalysis, pharmacokinetic data analysis and interpretation, biotransformation/disposition pathways, drug interaction risk assessment and human pharmacokinetics and dose predictions
  • Successful track record and experience in a DMPK lead role on multiple R&D teams across more than one therapeutic area
  • Strong mentoring and leadership skills, with emphasis on developing and coaching junior scientists to build a high-performing team
  • Ability to stay abreast and critically evaluate scientific literature and new technology as it relates to the discovery and development of new medicines
  • Excellent verbal, written and interpersonal communication skills, and ability to develop and grow strong cross-site/function collaborations

Fit with GBT culture:
  • Ability to build strong relationships with co-workers of various backgrounds and expertise
  • Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor
  • Values-based leadership consistent with GBT's Core Values
  • Excitement about the vision and mission of GBT
  • Flexibility
  • Integrity

NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization.

Global Blood Therapeutics is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or any other characteristic protected by law.