Eli Lilly and Company

Research Scientist-Protein Display/Engineering

Location
Greenfield, IN, United States
Posted
Jul 04, 2019
Ref
49288
Required Education
Doctorate/PHD/MD
Position Type
Full time
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Responsibilities
As a member of the Elanco Research Laboratories, this position will be responsible for designing and implementing a holistic veterinary antibody research platform that encompasses technologies to discover, engineer, and optimize therapeutic veterinary monoclonal antibodies. The position will require assessment, design, and implementation of a protein/antibody display platform that can be used across multiple projects. The incumbent will leverage contemporary and state-of-the-art technologies to minimize the hit to candidate timeline, while ensuring the right molecules are delivered the first time. This position will require routine interaction with senior scientists across multiple discovery and core research laboratories at Elanco. The incumbent scientist will be expected to support multiple projects at any given time. A strong foundation in molecular biology techniques and protein biochemistry will be required to proactively search for solutions in this discovery driven team.
  • Conceptualize, design, construct, and implement protein/antibody display platforms or similar systems for high to medium throughput functional screening of variants for affinity or thermostability optimization.
  • Conceptualize, design, construct, and implement methodologies for contemporary antibody discovery including single B-cell based approaches.
  • Conceptualize, design, construct, and implement platform(s) for the engineering (e.g, species-conversion, stability, effector function, expression, framework selection, LC/HC pairing) of biopharmaceuticals and, occasionally, vaccine antigens.
  • Develop vector sets and protocols for antibody engineering, including library design and construction, display platform optimization, panning/selection, and affinity determination.
  • Keep abreast of scientific literature in the field and implement novel modalities and protocols.
  • Provide expertise in evaluation of new platform technologies.
  • Proactively search for novel technologies or product opportunities and establish collaborations and research programs to deliver innovative technical solutions.
49288BR

Basic Qualifications
  • Minimum Ph.D. degree in a relevant scientific discipline (molecular biology, microbiology, cellular biology, or biochemistry)
  • 5 years of experience working on R&D projects in the human or animal health industries


Additional Skills/Preferences
  • Experience with protein/antibody display technology and/or automated high-throughput screening of protein/antibody variants.
  • Effective oral and written communications skills.
  • High personal ethical and quality standards.
  • Exceptional problem solving and decision-making skills.
  • Must be able to work productively in an interdisciplinary team environment
  • 10 years of experience working on R&D projects in the human or animal health industries
  • Proven project leadership skills
  • Demonstrated hands-on experience and knowledge of molecular biology techniques related to antibody/protein engineering including vector designs and display platforms
  • Knowledgeable in engineering novel functionalities into antibodies
  • Knowledgeable in functional engineering of enzyme and protein therapeutics
  • Experience with analytical and developability assays/techniques for detailed antibody characterization


Additional Information
Elanco is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status