ASSOCIATE SCIENTIST - ADME

Location
Birmingham, Alabama
Posted
Jul 03, 2019
Ref
Job ID 3394
Required Education
Bachelors Degree
Position Type
Full time

About Southern Research
We've created seven drugs that are helping win the war on cancer.  More are on the way.  When HIV threatened the work's future, we helped develop a course of treatment that changed the course of history.  We're creating better ways for you to have cleaner air and water.  Our technologies help men and women in uniform remain safe overseas.  We're developing methods to build energy efficient cars out of plant fiber that will get 80 mpg.  We are Southern Research.  We're taking on the world's hardest problems, and solving them.  This has been our mission since 1941.

Southern Research’s Drug Discovery Division is an active participant in and worldwide leader of ongoing drug discovery programs targeting various forms of cancer, a wide variety of neurologic and metabolic diseases, and a host of imminent viral and bacterial infections. We are a team of scientists who conduct basic research with a translational component as we identify small molecules that may become novel therapeutics for today’s most significant healthcare challenges. The multidisciplinary nature of drug discovery research is facilitated by Southern Research’s collaborative integration of biology, high throughput screening, and chemistry. In brief, a novel target is identified by our internal biological sciences group or through a collaboration, and a validated assay is established, which can then be used by our High Throughput Screening team on a large scale to identify “hits” for further investigation. Our Chemistry Department develops those hits to be more drug-like molecules through medicinal chemistry efforts, and eventually, synthesizes a potential drug. It can then be taken back to biological sciences for confirmation through mechanism of action studies and secondary assay performance. Eventually, these drug candidates are taken into clinical studies.

Aligned with our vision to lead and empower drug discovery, our internal research efforts are augmented by many collaborative relationships and external partnerships, including those from academic and industrial institutions. Our team-based system can be well-integrated into multi-centered project teams, as exemplified by ongoing projects. For example, a strong relationship exists with University of Alabama at Birmingham, through the Alabama Drug Discovery Alliance, launched in 2008 to facilitate and expedite the discovery and development of new drug therapies. We have formed a similar partnership with the University of Tennessee Health Science Center to advance promising research that could lead to new drugs that address unmet medical needs. Moreover, we are working to develop a new anti-cancer drug with Bionetix, a South Korean biotechnology company, through our newly developed collaborative research program. The division is also funded by multiple centers of the National Institutes of Health and other federal institutions, such as the Department of Defense. In addition, we have secured funding from several foundations such as the Cystic Fibrosis Foundation, Muscular Dystrophy Foundation, BrightFocus Foundation, Amyotrophic Lateral Sclerosis Association, Steven & Alexandra Cohen Foundation, Michael J. Fox Foundation, and Rheumatology Research Foundation.

General Summary
This position conducts In Vitro ADME studies and In Vivo pharmacokinetic sample analysis to advance small molecule drug discovery and development projects. Works closely with bioanalytical, ADME scientists, and medicinal chemists.

Key Responsibilities

  • Performs permeability and drug transporter assays to study ADME properties.
  • Conducts in vitro studies (CYP induction, CYP inhibition, protein binding, metabolic stability, metabolite profiling) and to quantify test compounds and metabolites in various matrices, including cells, plasma, microsomes and hepatocytes.
  • Analyze physicochemical properties of small molecule lead compounds (e.g. solubility, logD).

Position Specific

  • Performs experimental procedures under minimal supervision.
  • Capable of good record keeping of data and writing study reports
  • Effectively manages multiple projects simultaneously to meet internal/external deadlines
  • Provides technical solutions to a wide range of difficult problems.
  • Collects and analyzes data for review by technical staff using appropriate analysis software.
  • Consistently and reproducibly produces quality scientific data and analysis.
  • Will train less experienced staff.
  • Attends technical staff and departmental meetings.
  • Observes appropriate safety and study requirements by reading, understanding, and following Standard Operating Procedures (SOP), Good Laboratory Practice (GLP) requirements, and study protocols whenever appropriate.
  • Performs other duties as required by supervisor.

Requirements/Minimum Qualifications

  • M.S. degree in Chemistry, Biology, Drug Metabolism, Pharmaceutical Sciences and 1 to 3 years' relevant scientific experience, or B.S. degree and 4 to 6 years' relevant experience.
  • Ability to effectively communicate study designs and present data.
  • Proven ability to work as a member of a team.
  • Hands-on experience in mammalian cell culture, biochemical assays, and using multi-channel pipettes, laboratory automation devices.
  • Has a complete understanding of laboratory safety requirements.
  • Ability to troubleshoot and optimize assays.
  • Position works in a BSL-2 environment that requires Hepatitis-B vaccination (company will make arrangements for vaccination post offer, if needed).

Preferred Qualifications

  • Extensive cell culture experience and capable of performing permeability studies using Caco2, MDCK or similar cell lines.
  • Working knowledge of drug metabolism and transporter sciences.
  • Experience in tissue homogenization and sample processing (e.g. protein precipitation and Solid-Phase extraction).
  • Experience in operation of LC-MS/MS, HPLC instrument, and analyzing drugs in biological matrices.