Staff Scientist - Antibody Drug Conjugates (ADCs)

Location
Tarrytown, NY, United States
Posted
Jun 27, 2019
Ref
15696BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
The Therapeutic Proteins group is looking for a Staff Scientist to search and explore various types of small molecules in multi-therapeutic areas, lead in Medicinal chemistry optimization and develop new linkers and conjugation methods to conjugate and characterize novel antibody drug conjugates (ADCs).

Responsibilities
Key responsibilities include:

• Provide innovative and effective leadership in Medicinal chemistry optimization of early leads to candidate selection

• Design novel conjugation and characterization methods involving novel payloads and linkers, as well as conjugation sites.

• Design small molecular payloads and linkers, as well as linker-payloads, to be conjugated with proteins.

• Collaborate with cross-functional research teams and external CRO teams.

• Plan and effectively employ external chemistry resources deliver high quality compounds for biological evaluation

• Contribute to departmental strategies. Presentation of research programs at internal and external meetings

Experience with following additional skill and experience is plus:

• Solid-phase conjugation technology for parallel conjugations of antibodies with payloads to enable high-throughput conjugations to shorten ADC development timelines

• Bio-orthogonal conjugations, and implement site-specific and parallel conjugations, and perform purification and chariterization of ADCs.
Requirements:

• PhD in Chemistry with ~10 years of relevant industrial/academic research and drug discovery/development experience.

• Deep understanding of all aspects of small molecule drug discovery, including medicinal/process chemistry, biology, biomarker, pharmacology, DMPK, pharmaceutical sciences, safety and toxicology.

• Extensive research experience and knowledge to design and develop novel small moleculer bioactive compounds, and antibody drug conjugates (ADCs) and conjugation methods

• Excellent organization skills as an individual contributor and in leading or co-leading multidisciplinary drug discovery project teams are desired

• Excellent data analysis skills and strong verbal and written communication skills, as well experience understanding and drafting patent applications

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.