Senior Scientist II/III, Immuno-Oncology Pharmacology

Employer
AbbVie
Location
North Chicago, IL, US
Posted
Jun 25, 2019
Ref
1902383
Required Education
Bachelors Degree
Position Type
Full time
AbbVie (NYSE:ABBV) is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world's most complex and critical conditions. The company's mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter, Facebook or LinkedIn.

Our expanding In Vivo Tumor Biology group in Lake County, IL has an opening for a motivated individual who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics, with a focus on immuno-oncology. The individual will design/perform in vivo studies to understand how to effectively modulate the innate and adaptive immune system for new therapies. Our scientists interact with in vitro biology, translational/biomarkers, toxicology, clinical research, and medicinal chemistry teams to advance oncology agents through the R&D pipeline.

KEY RESPONSIBILITIES:
  • Designs and executes/conducts in vivo studies (syngeneic and humanized mouse models, as well as GEMMs) aimed at drug discovery in the immuno-oncology space
  • Uses detailed knowledge of state-of-the-art tools and approaches to enhance in vivo evaluation of novel therapeutics and/or identify new targets
  • Executes secondary cell-based assays across various technology platforms (e.g. FACS, cell sorting)
  • Performs supporting assays (immunophenotyping, cytokine profiling, ELISA and/or western blot analysis of tissue lysates) to assess target modulation levels and downstream effects
  • Participates in oncology target identification and validation
  • Demonstrates a high level of initiative in troubleshooting experiments and performing data analysis
  • Effectively collaborates across all intra and cross functional teams
  • Presents research findings to project teams and governance bodies and prepares technical reports
  • Works with external academic, biotechnology, and contract research organizations to advance our understanding of oncology diseases
  • Mentors and guides other scientists in the Department. Managerial experience that supports having direct report(s)


Level and compensation will be commensurate with experience.

Job Requirements:
  • BS, MS, or PhD in Immunology or a related discipline with 12+ (BS), 10+ (MS), or 4+ years of relevant research experience
  • Hands-on expertise to design and perform complex in vivo experiments utilizing tumor models in both immunocompetent and immunocompromised mice
  • Extensive knowledge of immuno-oncology biology
  • Extensive experience in cell, molecular and biochemical analysis of immune cells including lymphoid and myeloid cells using flow cytometry, cytokine release, immunofluorescence, cell proliferation, western, qRT-PCR, and other assays
  • Demonstrated excellence and productivity in independent research.
  • Proven publication record in immuno-oncology
  • Strong written and verbal communication skills
  • Scientific leadership abilities and collaborative personality
  • Detail-oriented, with excellent organizational and record-keeping skills

Preferred Requirements:
  • Ph.D and 5+ years of experience
  • Experience in the pharmaceutical or biotechnology industry
  • Knowledge of humanized models, cell line-derived xenograft models, and genetically engineered mouse models
  • Experience with CRISPR and other related technology in both in vitro and in vivo settings

Key Leadership Competencies:
  • Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment
  • Entrepreneurial personality, with problem solving skills, critical thinking ability, and excellent communication skills
  • Highly motivated and independent with an ability to adapt to changing priorities in a fast-paced environment
  • Raises the bar and is never satisfied with the status quo
  • Excited to participate in and contribute to company culture
  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
  • Learns fast, grasps the "essence" and can change course quickly where indicated
  • Creates a learning environment, open to suggestions and experimentation for improvement
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality