Associate Scientist I/II, Proteostasis Biology in Neurodegeneration

Cambridge, MA, US
Jun 25, 2019
Required Education
Bachelors Degree
Position Type
Full time
Our AbbVie Foundational Neuroscience Center (FNC) located in Cambridge, MA was established to investigate the biological mechanisms underlying neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Our scientists are using this understanding of disease processes along with state-of-the-art technologies to develop transformative treatment options for patients.

We are seeking a highly motivated scientist with a passion for drug discovery. As the associate scientist, you will be responsible for generating and differentiating iPSC-derived neurons, using high content imaging to measure cellular changes corresponding to neurodegeneration, conducting exploratory experiments into basic disease biology, and working in multi-disciplinary teams to advance novel therapeutic approaches to the clinic.

Key Responsibilities Include:
  • Work with an existing team to derive, culture and differentiate multiple human iPSC lines into NPC's and neuronal cultures
  • Coordinate with other scientists to design, execute, and analyze cell-based experiments utilizing immunocytochemistry and imaging techniques
  • Formalize scientific contributions by maintaining detailed electronic laboratory notebooks, writing SOPs, and presenting at team meetings
  • Maintain a healthy, safe, and inclusive work environment

Position will be hired based on level of experience.
  • Bachelors or Master's degree in cell biology, molecular biology, neuroscience or closely related field with typically 0-4+ (BS), or 0+ (MS) years of experience
  • 1-3+ years of experience in a laboratory setting is preferred
  • Demonstrated excellence in planning, organizational skills and attention to detail
  • Proficiency with standard cellular and biochemical techniques including sterile tissue culture, microscopy, and gene transfer methods (with preference given to candidates with prior work with iPSCs).
  • Proven ability to understand, execute and interpret critical experiments and generate reproducible results
  • Excellent written and verbal communication skills
  • Commitment to teamwork with a penchant to work productively and creatively in a multi-disciplinary environment
  • Familiarity with standard Microsoft applications, statistical packages, and gene editing software