Scientist II, In Vivo Pharmacology

South San Francisco, CA, US
Jun 25, 2019
Required Education
Bachelors Degree
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of noveloncology therapies. More than 1,000 AbbVie scientists, statisticians, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie's South San Francisco oncology site.

We are looking for a Scientist I/II with experience in in vivo pharmacology and optical imaging study execution, start to finish including tumor implantation, data collection, and data analyses. Additional opportunities to learn new skills and to work on ex vivo lab experiments will be provided depending on the project and candidate's interests. The ideal candidate will have experience working with various mouse models of cancer. Above all, we are looking for a highly motivated and collaborative individual with a passion for oncology research, who enjoys working in a fast-paced and highly dynamic working environment.

  • Execute in vivo studies involving CDX, PDX, systemic models, syngeneic models, etc. for various cancer subtypes
  • Evaluate novel cancer therapeutics in vivo through studies such as efficacy, PK, tolerability, and imaging
  • Monitor and execute in vivo studies
  • Collect and process tissue/blood samples
  • Analyze and report data regularly at team meetings

Scientist I: BS degree with typically 5 or more years of relevant experience, or MS degree with typically 2 or more years of relevant experience

Scientist II: BS degree with typically 7 or more years of relevant experience, or MS degree with typically 5 or more years of relevant experience
  • Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation, tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection, minor surgical procedures
  • Experience with mouse models of cancer, including CDX (cell line derived) and/or PDX (Patient Derived Xenograft) models preferred
  • AALAS certification is preferred but not required
  • In vivo imaging experience with optical imaging (bioluminescence/fluorescence) is desired, but not required
  • Cell culture experience desired but not required
  • Excellent laboratory, record keeping, data analysis, and critical thinking skills
  • Willing to have schedule flexibility and to split weekend and holiday hours with peers on a rotational basis
  • A team player with excellent verbal and written communication skills
  • Strong organizational skills, attention to detail, and time-management skills enabling efficiency and independence