Applied Protein Chemist for Biomarker Development
- Employer
- Frederick National Laboratory for Cancer Research
- Location
- Frederick, MD, USA
- Start date
- Jun 25, 2019
View more
- Discipline
- Science/R&D, Chemistry
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- BioCapital
Job Details
KEY ROLES/RESPONSIBILITIES
The Scientific Project Manager II/Protein Chemist for Biomarker Development will help to establish and oversee a state-of-the-art protein chemistry laboratory focused on development and validation of conjugated antibodies used for clinical specimen analyses.
Specific responsibilities include:
- Oversee and execute the development of novel antibodies using a variety of approaches such as mouse and rabbit hybridomas, and phage display including antigen design, immunization strategies, serum titer evaluations, cell fusions, scale up and antibody characterization in collaboration with scientific staff within the CPP program
- Act as a technical project manager to establish and oversee subcontracts to custom antibody suppliers for the development, production and characterization of novel antibodies
- Oversee and execute the characterization of antibodies, antibody conjugates and recombinant proteins using fit-for-purpose, current analytical techniques
- Design and execute methods leading to the development of optimal protein bioconjugation procedures (fluorescent dyes, haptens, DNA barcodes) for antibodies in support of novel multiplex assay development
- Facilitate process transfer and scale up of optimized bioconjugation processes with subcontractor
- Recruit, train and supervise scientific staff in generation of materials and data necessary to support the primary experimental objectives of the program
- Provide regular updates to program leaders through preparation of formal reports and presentations
BASIC QUALIFICATIONS
- Possession of a Doctoral degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in a field related to protein chemistry, protein engineering, or related field in clinical diagnostics or medical imaging using antibodies. Foreign degrees must be evaluated for U.S. equivalency.
- In addition to educational requirements, at least five (5) years of combined experience in protein analytical methods, protein bioconjugation methods and antibody development
- Significant experience in the following areas: antibody design, development and characterization; optimized protein conjugation methods; current quantitative protein analytical methods
- Collaborate with a diverse group of scientific staff responsible for development and validation of clinical pharmacodynamic assays across several platforms, internal critical reagent supply chain and incoming quality control testing and external subcontractors performing key aspects of reagent development and characterization.
- Experience supervising laboratory staff from the entry level technician through Ph.D. level bench scientists
- Hands-on experience with instrumentation
- A record of publication in refereed scientific literature
- Ability to maintain precise records
- Must be able to obtain and maintain a security clearance
PREFERRED QUALIFICATIONS
- Experience with one or more of the following techniques: Sandwich ELISA, Luminex assays, slide based multiplex immunofluorescence assay staining and analysis methods, immunoassay development, antibody conjugation and protein purification
- Ability to independently develop, modify methods and techniques
- Proficiency with Microsoft Office (Excel, Word, and PowerPoint)
- Experience working in a GxP environment. Quantitative laboratory work in biochemistry, biology, chemistry, biotechnology
- Experience in supervising laboratory staff from the entry technician level through Ph.D. level bench scientists
- Outstanding English language communication skills are required. Ability to communicate with program lead researchers in a demanding scientific environment through preparation of formal reports and presentations
Company
A rewarding career with global impact
Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.
Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.
We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.
Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.
Discover why joining the Frederick National Laboratory team could be the most important career step you take
- Website
- https://frederick.cancer.gov/
- Phone
- 301-846-1000
- Location
-
8560 Progress Drive
Frederick
MD
21701
US
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