Principal Engineer - Modeling and Simulation
Amgen discovers, develops and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe, effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives.
Amgen's Digital Integration and Predictive Technologies organization is a global process development function that develops and deploys state of the art advanced computational technologies in: 1) data capture, integration and management, 2) empirical and first principles modeling towards improved process understanding and robustness, and 3) monitoring, prediction and optimization of manufacturing.
We are seeking a Principal Engineer to lead development, application, and deployment of rigorous mathematical models of drug delivery device technologies. The candidate will apply structural, fluid, biomechanical, and multi-physics theory to develop novel first-principles and mechanistic computational models addressing a wide variety of challenging problems associated with device design control, characterization, verification and validation. Responsibilities will include integration of computational modeling and simulation in the device development process, management and expansion of a device modeling portfolio, identifying design problems suitable for in-silico evaluation, formulating mathematical representations of design questions, formulating constitutive and governing equations describing physical phenomena, implementing models in commercial and proprietary software, and deploying these models to internal users via an enterprise modeling infrastructure.
It is expected that the Principal Engineer will collaborate heavily with internal stakeholders and leaders in injection device design and development, as well as document and communicate the underlying technical basis of the models for the benefit of and use by the broader engineering and scientific community responsible for design and manufacture of drug delivery devices. Experience in mathematical and computational (in-silico) modeling is required, and experience in medical device development and engineering is highly desired.
Doctorate degree and 2 years of experience directly related to the job in Mechanical, Aerospace, or Biomedical Engineering
Master's degree and 6 years of experience directly related to the job in Mechanical, Aerospace, or Biomedical Engineering
Bachelor's degree and 8 years of experience directly related to the job in Mechanical, Aerospace, or Biomedical Engineering
Associate's degree and 10 years of experience directly related to the job in Mechanical, Aerospace, or Biomedical Engineering
High school diploma / GED and 12 years of experience directly related to the job in Mechanical, Aerospace, or Biomedical Engineering
- Doctorate degree 8 years of experience directly related to the job/ Master's degree and 12 years of experience in Mechanical, Aerospace, or Biomedical Engineering with experience noted in the basic qualifications above.
- 5+ years relevant work experience in active medical device design.
- Modeling of structural or fluid mechanics and/or mechanical devices.
- Experience with commercial structural and fluid dynamics simulation software (e.g. ANSYS, Fluent, COMSOL)
- Good understanding of the regulatory process and requirements.
- Basic programming skills
- Strong interdisciplinary project management skills.
- Ability to independently uncover and resolve issues associated with design engineering projects.
- A good record of scientific publications, ideally related to the qualifications above.
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.