Associate Scientist II / Scientist I, Tumor Biology

Employer
AbbVie
Location
South San Francisco, CA, US
Posted
Jun 22, 2019
Ref
1903671
Required Education
Bachelors Degree
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of noveloncology therapies. More than 1,000 AbbVie scientists, statisticians, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie's South San Francisco oncology site.

The Tumor Biology group within Oncology Discovery is looking for a Scientist with experience in cell and molecular biology. Specifically, this position will require skills in flow cytometry, cell culture, tissue (PDX) processing, as well as standard molecular biology and biochemical techniques. Above all, we are looking for a highly motivated and collaborative scientist with a passion for basic and translational cancer research, who enjoys working in a fast-paced and highly dynamic working environment.

KEY RESPONSIBILITIES INCLUDE:
  • Characterize primary human tumors and PDX by flow cytometry and process them for downstream applications, such as single cell RNAseq
  • Manage PDX bank, support in vivo studies (PDX, systemic models, syngeneic models, etc.)
  • Perform in vitro studies with established cancer cell lines and primary cells
  • Explore mechanism-of-action and biomarker hypotheses for novel combinations, as needed
  • Perform cell-based or biochemical assays
  • Analyze and report data regularly at team meetings


Associate Scientist II: Bachelor's Degree in biochemistry, biology, or equivalent education, with typically 3 or more years' experience or Master's Degree or equivalent education

Scientist I: Bachelor's Degree in biochemistry, biology, or equivalent education with typically 5 years of experience, or Master's Degree or equivalent education with typically 2 years of experience.
  • Technical expertise in cell and molecular biology and/or cancer biology
  • Experience with mouse models of cancer, including PDX (Patient Derived Xenograft) models preferred
  • Multi-color flow cytometry experience preferred
  • Excellent laboratory, record keeping, data analysis, and critical thinking skills.
  • Ability to plan, execute, and troubleshoot experiments.
  • Ability to manage more than one project at any given time and to work successfully in across-functional and highly collaborative team environment
  • Exceptional communication, both speech and writing, to a variety of audience types
  • Excellent working knowledge of Microsoft Word, Excel, PowerPoint, FlowJo and GraphPad Prism