Scientist, Bispecific Antibodies

Location
Tarrytown, NY, United States
Posted
Jun 19, 2019
Ref
16713BR
Required Education
Doctorate/PHD/MD
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking an experienced and motivated Scientist to join the Bispecific group, a multidisciplinary team that designs and evaluates novel bispecific and alternative antibody formats across multiple therapeutic areas. The successful candidate will be responsible for designing, executing and analyzing preclinical in vivo and in vitro/ex vivo experiments to evaluate the efficacy and explore the mechanism of action of immune modulating antibodies to treat cancer. Ideal candidates will possess a deep understanding of immunology principles, and extensive laboratory experience in cellular biology/immunology with a focus or experience on in vivo mouse modeling. Ideal applicants will possess excellent interpersonal and communication skills, as this candidate will be expected to work productively in a collaborative, cross-functional team environment and efficiently present her/his findings to internal multi-disciplinary teams.

Responsibilities
  • Design, plan, and independently perform complex in vivo experiments, including establishing novel tumor models in immune compromised and immune competent mice.
  • Design complex flow cytometry (FACS) panels and perform FACS analysis on human and murine cells, tumors, and tissues.
  • Perform a variety of in vitro/ex vivo immune cell-based assays, such as FACS based cytotoxicity and serum/supernatant analyte analysis (ELISA, MSD, CBA).
  • Analyze data using biological and statistical software such as Flowjo, Prism, Excel, and algorithmic tools for high-dimensional cytometry data analysis (tSNE, SPADE, FlowSOM, etc)
  • Document experimental procedures and results in a well-organized fashion; generate experimental reports.
  • Participate in general lab duties of the team
  • Synthesize results across experiments and programs in PowerPoint presentations and present to colleagues and senior management, including clinical and regulatory teams.
  • Collaborate closely with cross-functional teams across the company.
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Requirements
  • PhD + 3+ years post-doctoral or industry experience
  • Strong background in cellular and molecular immunology and/or immuno-oncology; experience with protein therapeutics, such bispecific or novel antibody formats, is desirable
  • Experience with designing and performing all aspects of tumor modeling in mice, including mouse handling, tumor/therapeutic implantation/injection (iv, ip, sc), tumor growth monitoring, and dissection of mouse lymphoid organs and tumors, followed by in vitro processing/purification of tissues/cells.
  • Extensive knowledge and practical experience with advanced flow cytometry including complex panel design for cell surface and intracellular staining, data acquisition and analysis.
  • Experience in cell culture (both primary cells and established cell lines), and the execution of a variety of in vitro/ex vivo immune cell-based assays


This position will require the individual to pass a physical before beginning employment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.