Pharmacokinetics & Drug Metabolism - Sr Associate Scientist

South San Francisco, CA, US
Jun 18, 2019
Required Education
Bachelors Degree
Position Type
Full time
In our mission to serve patients, speed is absolutely critical. We're rapidly expanding our hiring initiatives and are excited to unite with the most passionate and brilliant scientific minds who want to join our team - working toward our mission of advancing high potential programs for patients around the world.

The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Job Description

In this position you will work as a member of the small molecule ADME group and your core responsibilities are to:
  • Execute enzyme kinetics, in vitro inhibition, metabolite identification, and bioanalytical experiments.
  • Implement bioanalytical methods for the quantitative and qualitative analysis of small molecule drug candidates and metabolites in plasma, tissues, and other biological matrices.

The ideal candidate will have a proven ability to execute experiments to quantitate molecular entities by mass spectrometry in support of both drug discovery and early development programs. This role requires an understanding of preclinical ADME and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment. The candidate should be able to instruct others on implementation of developed assays and assist in troubleshooting when instrument or other problems arise. Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.

Basic Qualifications

Master's degree and 3 years of Scientific experience
Bachelor's degree and 5 years of Scientific experience

Additional Qualifications:
  • BS or MS, or PhD in chemistry, biochemistry, or related field is required.
  • Experience with operation, troubleshooting, and data interpretation of a mass spectrometer is required
  • Experience with operation of automated liquid sample handling instruments and/or experience with analysis of radiolabeled compounds is a plus.
  • Effective oral and written communication skills
  • Aptitude to thrive in a fast-paced, highly collaborative, matrixed team environment.

We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.