Senior Research Associate, T Cell Biology

Employer
Celgene
Location
Seattle, Washington, United States
Posted
Jun 17, 2019
Ref
1804528
Required Education
Bachelors Degree
Position Type
Full time
Req #: 1804528
Location: Seattle, Washington, United States
Job Category: Research and Early Development
Work Location: 400 Dexter Ave N. 98109
Organization: Translational Medicine
Employee Status: Full-time
Job Type: Regular

The Celgene Immune-Oncology and Cell Therapy Center of Excellence is dedicated to research supporting development of novel cellular immunotherapies based on two distinct and complementary platforms - Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) technologies. Our goal is to revolutionize medicine by re-engaging the body's immune system to treat cancer.

We are looking for a motivated scientist to join our T Cell Biology & Engineering team. This team member will develop and execute novel platforms to generate biological enhancements to CAR-T cells, using new and emerging technologies to modify genetic pathways in CAR-T cells and employing a range of cellular T cell profiling and functional assay endpoints to evaluate promising leads.

Responsibilities will include but are not limited to:
  • Design and execute cell-based experiments to support exploratory research in preclinical development
  • Perform cell biology, molecular biology, and biochemical techniques including cellular immunology and T cell functional assays including proliferation assays, intracellular cytokine staining, and Luminex/ELISA., multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, gene editing or knockdown, immunoprecipitation, and western blotting.
  • Keep up with latest technological and scientific approaches to Immuno-Oncology research using literature and other sources.
  • Collaborate effectively and cultivate positive and productive relationships with other scientists within and outside Celgene.
  • Present to manager, project team and work groups, provide scientifically rigorous analysis and review of data and help plan next steps.
  • Contribute to written invention disclosures, internal and external regulatory reports as needed.
    Participate in maintenance of routine laboratory instrumentation and supplies.
  • Adherence to laboratory safety policies and practices.
  • May supervise other research associates as needed.

Minimum Qualifications:
  • Bachelor's degree in a scientific discipline with at least 4 years work experience or Master's degree with at least 2 years work experience in immunology research.
  • T cell biology including understanding of the role of T cells in health and disease, the significance of T cell subsets and their functional interactions in the tumor microenvironment.
  • High-parameter (10+ color) flow cytometry (FACS), T cell culture, Luminex, microscopy, RNA and protein purification and analysis (Taqman and western blot), including demonstrated capability to analyze and interpret data.
  • Ex vivo genetic manipulation of primary T cells, including viral and non-viral gene delivery.
  • Planning skills to execute on multiple work streams and provide timely and prioritized results
  • Capability to independently troubleshoot in a fast-paced dynamic environment, with flexible and changing priorities in a multi-disciplinary, multi-site team oriented environment.
  • Excellent communication skills with experience preparing public presentations and/or peer-reviewed manuscripts.
  • Strong personal initiative, flexibility and innovative approach to problem solving are required.
Preferred Qualifications:
  • Experience with development and execution of high-throughput functional screening, including use of robotics for high-throughput liquid handling and cellular analysis.
  • Prior experience with gene editing approaches such as CRISPr, TALENs or ZFNs.
    High-content data analysis of large sample sets; ability to adopt new approaches to high-content data analysis and visualization.

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About Us

COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

"At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.