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Associate Scientist, Gene Editing and Cell Therapy

Employer
Celgene
Location
Seattle, Washington, United States
Start date
Jun 17, 2019

View more

Discipline
Clinical, Science/R&D, Biotechnology, Biotherapeutics
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

Req #: 1901632
Location: Seattle, Washington, United States
Job Category: Research and Early Development
Work Location: 400 Dexter Ave N. 98109
Organization: Translational Medicine
Employee Status: Full-time
Job Type: Regular

Celgene is looking for a highly motivated, dynamic and self-driven individual to join the Immuno-Oncology & Cellular Therapy Gene Editing team in Seattle. Reporting to a Sr. Scientist, the primary focus of the Associate Scientist role will be to develop and expand our internal gene editing capabilities as well as to develop and validate downstream in vitro functional assays for edited cells within the context of CAR T cell therapy development.

Objectives of this position:
  • Design, implement and optimize gene editing experiments, including assays to evaluate gene editing both functionally and molecularly
  • Show competency in editing and functional testing of primary T cells;
  • Help develop novel tools/assays for clinical gene editing applications.

Primary Responsibilities:
  • Work to develop and improve gene editing protocols and reagents (including repair template design for homology directed repair) for single and multiplexed gene editing applications.
  • Work with other team members to develop and evaluate technical feasibility of novel gene editing delivery methods.
  • Set up and run assays to evaluate levels of gene editing in primary T cell products.
  • Culture gene-edited primary human T cells and test their functionality and specificity thru a variety of immunological assays.
  • Spend most of the time in the lab, keep very detailed notes on experiments and update the group on lab progress.

Minimum Qualifications:
  • Bachelor's degree in a scientific discipline with at least 6 years work experience or Master's degree with at least 4 years relevant work experience in relevant field of research (molecular biology, immunology, genome engineering or a related discipline).
  • Hands-on experience with gene editing technologies (CRISPR/Cas9 preferred), for both knock-out (gRNA design, RNP formulation, Indel measurement, etc) and knock-in (expertise in repair template design) applications using viral and non-viral delivery mechanisms in human cell lines and primary cells.
  • Relevant skills include experience in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays, ELISA, etc.) and molecular biology techniques (cloning, PCR, RT-PCR, mRNA and DNA prep).
  • Experience with assay development, qualification, and validation.
  • Ability to multitask, independently organize time, and plan specifics of work.
  • Excellent communication and facilitation skills demonstrated in a team environment.
  • Willingness to think outside the box, be creative and ability to work in a very fast paced, ever changing environment.

Preferred Qualifications:
  • NextGen sequencing or single cell molecular analysis.
  • Prior experience with panel design for multi-color flow cytometry and downstream data processing/analysis, a plus.


About Us

COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.

"At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."

There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.

Company

At Celgene Corporation, we’re committed to changing the course of human health through bold pursuits in science, life-enhancing therapies and a promise to always put patients first. As a global leader in biotechnology and CAR T cell therapy, Celgene is a place where employees can make a real impact on the lives of patients with unmet medical needs in cancer and inflammatory diseases.

As we rapidly advance our next wave of innovative medicines, we announce the creation of a new global Clinical Development Organization to accelerate and optimize clinical development across our entire mid- to late-stage portfolio. Our commitments in this area will further establish the function as a center of excellence and enhance our strategic leadership in discovery, development and commercialization.

Recognized by Forbes in 2018 as a Top 10 World’s Best Employer and by Business Insider as the #3 Most Reputable Pharma Company in the World, Celgene offers a unique work environment where you can help build the business, while building your career in ways you may not have thought possible. We’re looking for innovative self-starters who want to improve the lives of patients worldwide. For more information, visit https://www.celgene.com/careers/.

Company info
Website
Phone
908-673-9000
Location
Corporate Headquarters
86 Morris Avenue
Summit
New Jersey
07901
US

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