Research Associate IV, Antibody Engineering & Technologies

South San Francisco, CA, United States
Jun 15, 2019
Science/R&D, Research
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases. Our industry-leading drug discovery platform, which includes comprehensive proprietary libraries of the extracellular proteome and differentiated screening capabilities, has led to a pipeline comprising five development programs in clinical trials across multiple indications in 2019. We also have several undisclosed research programs that have the potential to yield our next wave of development-stage therapeutic biologics. And we continue to fuel this process using our proprietary screens to discover new immuno-oncology targets.

Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. We value our culture of openness, collaboration and productivity. Discover more about FivePrime at

Job Description

We are looking for a highly motivated Research Associate IV with strong expertise in flow cytometry and cell sorting to join the Antibody Engineering and Technologies Group within the Biotherapeutics Department. The successful candidate will manage the FACS core and play a key role in the discovery and development of antibody-based therapeutics in the immuno-oncology field. She/he will support the cell sorting and flow cytometry needs of multi-disciplinary project teams. In addition, he/she will support antibody characterization and implement technology development within the Antibody group. She/he will take a leading role in experimental design, execution, and in communicating results. The candidate must hold a Bachelor's or Master's degree in related field plus 3 - 5 years relevant experience, preferably in an industry setting. (Level commensurate with experience).


  • Proficient in cell sorting utilizing BD FACSAria-III including set-up, operation, maintenance, and troubleshooting
  • Skilled with instrument set-up, support, operation, maintenance, and troubleshooting on a range of flow cytometers including BD Fortessa and LSR-II
  • Experience in design and execution of multicolor, FACS-based screening assays
  • In-depth knowledge of FlowJo and FACSDiva
  • Ability to analyze, interpret and communicate scientific data

Desired skills & Experience:
  • Spectral flow cytometry experience (theory, panel designs).
  • Hands-on with Cytek Aurora analyzer is a plus
  • Experience with using ThermoFisher's Attune NxT cytometer is a plus
  • Experience with mammalian cell culture
  • Molecular biology experience in cloning, PCR, and building NGS libraries is a plus
  • Good understanding of antibody discovery technologies and/or antibody characterization is desirable but not essential

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.