Scientist II

Worcester, MA, US
Jun 14, 2019
Required Education
Bachelors Degree
Position Type
Full time
The Discovery team at the AbbVie Bioresearch Center in Worcester, MA is looking for a Scientist to join their team to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.
  • Optimization and validation of conjugation protocols and formulation buffers.
  • Optimization of automated techniques for ADC synthesis and purification

  • BS or MS degree with 7+ (BS) or 5+ (MS) years of experience in Analytical Chemistry, Biochemistry, Chemistry or other relevant discipline.
  • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.
  • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired.
  • Hand on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).
  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.