Research Associate II, BioAnalytical Research and Development (BARD)
- Employer
- BioMarin Pharmaceutical Inc.
- Location
- San Rafael, CA, United States
- Start date
- Jun 13, 2019
View more
- Discipline
- Regulatory, Science/R&D, Bioanalytical Services, Research
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay, Best Places to Work
Job Details
BioAnalytical
Research and Development (BARD)
SUMMARY
BioAnalytical
R&D (BARD) develops analytical methods for detection of drug, antibodies to protein therapeutics, and biomarkers in biological matrices from non-human and human subjects to support projects through multiple stages of development. The Research Associate II (RA
II) will design and execute technically complex experiments to support these projects. They will provide quantitative data analysis, interpretation of results, and contribute to technical reports (e.g. assay qualification and validation reports, SOPs). The RA II evaluates complex methods and technologies, identifies new areas requiring process improvement and adapts existing processes or develops new ones with direct input and supervision from a manager. The RAII also evaluates new lab equipment, recommends vendors, and provides assistance to assay development, troubleshooting , and validation.
They may contribute to scientific publications and regulatory submissions as required.
RESPONSIBILITIES
Develop a variety of analytical methods to detect drug, antibodies to protein therapeutics, and biomarkers in biological ma trices. Techniques may include but are not limited to
protein purification/chromatography, nucleic acid extraction,
droplet digital and quantitative
polymerase chain reaction (PCR)
assays ,
Western blot
assays ,
enzyme-linked immunosorbent assays (ELISA),
electrochemiluminescence
assays (ECLA),
and
enzyme activity
and cell-based assays.
Qualify selected assays or reagents for transfer to
BioAnalytical
Testing and validation.
Participate in management and oversight of assay development and validation projects outsourced to contract research organizations (CROs).
Analyze data, including basic statistical and graphical analysis.
Present results, conclusions, and implications to
the
BioAnalytical
Sciences
group.
Develop new techniques, or bring in new technology from the outside, to enhance the analytical capabilities of the group.
Prepare SOPs and other reports and documents to support nonclinical and clinical programs and associated regulatory submissions. This includes qualification protocols, qualification reports, memoranda, and data reports for testing results.
Share responsibility for lab management duties.
Participate and present data as a member of
BioAnalytical
teams, and share responsibility for project milestones.
Present data and participate in discussions in Research/ Pharmacological Sciences/Translational Sciences (RPT) team meetings as necessary.
Participate in external scientific meetings and contribute to original peer-reviewed publications.
Other duties as assigned.
EXPERIENCE
Bachelors degree in a scientific discipline or equivalent with 2-4
years experience
with assay development and validation, or Masters degree with 1-2
years experience . Broad technical proficiency. Ability to solve moderately complex issues independently. Familiar with GLP requirements. Excellent verbal and written communication skills. Ability to use computer effectively for data analysis and presentation.
EDUCATION
Bachelors or
Masters
degree
in Biology, Chemistry or related field.
Bachelors with 4
years experience
- OR - Masters with 2 years of experience working with immunoassays, biomarker assays, or other analytical methods.
Working knowledge of cell biology and biochemistry.
EQUIPMENT
Multi-well absorbance and fluorescence plate reader s
and associated software.
Centrifuges and incubators
Windows network environment, MS Office, etc.
Electronic Laboratory Notebook
~BIO
Company
BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.
Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.
Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.
- Website
- https://www.biomarin.com/
- Location
-
California
United States
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