Bristol-Myers Squibb Company

Senior Research Scientist (In Vivo Pharmacology)

Location
Cambridge, MA, United States
Posted
Jun 13, 2019
Ref
R1516221
Required Education
Bachelors Degree
Position Type
Full time
The Research Scientist In-Vivo Pharmacology will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The position will utilize in vivo models and immunological techniques to profile novel therapeutics and identify and validate targets that confer resistance to immunotherapies.

The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the Discovery Oncology, immunology, protein engineering/antibody development and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.

Qualifications
  • A B.S. with a minimum of 10 years, or an M.S. with a minimum of 7 years of industrial experience with strong scientific knowledge and research experience in in vivo pharmacology, cancer biology, immuno-oncology, or immunology is highly desirable.
  • Extensive knowledge of preclinical drugdevelopment including knowledge of independently designing and conducting in vivo and ex vivo experiments to identify and profile drug candidates is required.
  • Demonstrated independence in designing, executing, and analyzing data from in vivo studies with tumor bearing mice is required.
  • Experience with syngeneic tumor models is preferred; experience with GEMMs is a plus.
  • Required skills include: model development, tumor implantation, animal identification and randomization, dosing via IV, IP, SC, I-TUMOR and PO routes, tumor measurements by caliper, blood draws by tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses
  • Proficiency in designing multi-color FACS panels and using them to characterize tumor infiltrating lymphocytes is very highly desirable.
  • Proficiency in cell culture and ex vivo techniques such as qPCR, ELISA (MSD), or WB is required.
  • Experience with surgical procedures to enable development of orthotopic tumor models and using ultrasound to monitor orthotopic tumor growth is desirable.
  • Experience conducting in vivo pooled genetic screens is desirable.
  • Proficiency in utilizing software such as Graph Pad, FlowJo, Microsoft office etc. for data analysis and figure generation is required.
  • Demonstrated ability to mentor junior scientists and colleagues on best practices in the laboratory would be highly valued.
  • Attention to detail with excellent organizational and record keeping skills is a requirement.
  • Ability to thrive as a member of a diverse and motivated team of researchers spanning across the Oncology Discovery group is a requirement.


Responsibilities include:
  • Independently design and conduct mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, animal identification and randomization, dosing via IV, IP, SC, I-TUMOR and PO routes, tumor measurements by caliper, weighing, health monitoring, tissue sampling by fine needle biopsy and core needle biopsy, peritoneal lavage, blood draws by retro-orbital, tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses
  • Train and mentor junior associates on best practices (in vivo and ex vivo)
  • Establish complex orthotopic tumor models
  • Utilize ELISAs (MSD), qPCR, or WB to monitor biomarkers in harvested tissues
  • Lead or contribute to the utilization of multi-color flow cytometry to profile the immune infiltrate in harvested mouse tissues.
  • Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook.
  • Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.
  • Work as a member of a diverse and motivated team of researchers spanning across the Oncology Discovery group and other line functions.
  • Rotating weekend, holiday and off-hour on-site responsibilities to support BID/QD dosing may be expected of this position.
  • This position is located in Cambridge, MA. There will be less than 10% travel.