Scientist, In Vitro Pharmacology

06340, Groton
Jun 06, 2019
Required Education
Bachelors Degree
Position Type
Full time

Pfizer colleagues have many perspectives, many backgrounds, and many strengths, but we share one goal: to improve the lives of patients. Worldwide Research and Development (WRD) combines research units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies.

The successful candidate will join a team of ~50 scientists within the Primary Pharmacology Group (PPG) at our Groton, CT campus, focused on the design, development, and execution of in vitro plate-based screening assays supporting hit identification and lead optimization for small molecule drug discovery programs across Pfizer Research Units.  Disease areas of focus for the group include Inflammation and Immunology, Cardiovascular/Metabolic, Rare Diseases, and Oncology.  Working collaboratively with project teams, (s)he will autonomously provide assay development and small molecule screening support to both target-based and phenotypic programs, ensuring support from project idea to clinical candidate selection.   


Applicants must have experience working independently in a laboratory setting and a broad understanding of biology.  Previous experience in 3 or more of the following is required: plate-based pharmacology, cell biology, biochemistry, enzymology, drug discovery, laboratory automation.  Also critical to the role is a demonstrated ability to rapidly become proficient with new technologies, equipment and software (e.g. screening techniques and equipment, ABase, GraphPad Prism, Spotfire). The successful candidate will be excited by working in teams with multiple partners (e.g. Chemistry, Research Unit Biology, Structural Biology, and CROs).  In addition to sound technical skills, the candidate should therefore possess strong collaborative and written/verbal communication skills, be adept at building partnerships, and display flexibility/resiliency and a good sense of humor. 


At Pfizer, we believe in helping people lead healthier lives — from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs.  The Primary Pharmacology Group offers a collegial and supportive environment for colleagues, with a culture encouraging openness, innovation and ownership of our science. We aim to provide scientific and growth opportunities for personal and career development commensurate with a colleague’s goals and experience. 


  • We seek a laboratory scientist to support hit identification and lead optimization for small molecule drugs discovery projects.
  • This scientist will participate in designing in vitro pharmacology strategies for target-based and phenotypic projects. Working with the team, (s)he will develop, optimize, and perform in vitro assays to drive lead identification and SAR using a combination of biochemical, target-based, and physiologically relevant assay systems.  (S)he will carry out data analysis as well as review and interpret this data for project teams.
  • This scientist will have the opportunity to work on cutting-edge science using novel technologies applied to portfolio advancement.
  • This scientist will work with an interdisciplinary team of Research Unit biologists, medicinal chemists, structural biologists and biophysicists, as well as external partners to deliver on the portfolio.


  • BS or equivalent with 6+ years of experience relevant to drug discovery in biochemistry, cell biology, and/or pharmacology OR MS with 5+ years of relevant industry experience
  • Demonstrated experience with several in vitro assay formats (e.g. FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, etc.), including troubleshooting
  • Practical experience with cell culture, laboratory automation, and data analysis systems
  • Demonstration of excellent computer, verbal and written communication skills


  • Previous experience in multiple target classes (e.g. GPCRs, transporters, kinases, ion channels,…) in a drug discovery setting
  • Knowledge of associated disciplines such as functional genomics, molecular and cellular biology, protein chemistry, biophysical techniques and chemistry.


Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.

Other Job Details:

  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Package