Bristol-Myers Squibb Company

Research Investigator (In vivo target ID & pharmacology)

Location
Cambridge, MA, United States
Posted
Jun 06, 2019
Ref
R1515353
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Research Investigator will join the Discovery Pharmacology and In Vivo Biology Group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The successful candidate will possess expertise in mouse tumor models and in vivo pooled CRISPR screens and leverage these skills to drive in vivo target identification efforts. The successful candidate's team will also plan, execute and analyze preclinical in vivo studies, e.g. PK/PD and efficacy, interrogating our immuno-oncology and resistance biology portfolio.

The qualified candidate is a highly motivated, creative, and collaborative individual that possesses the ability to work across a highly matrixed environment and communicate effectively with multidisciplinary teams and key stakeholders. You are expected to leverage your experience and skills to train and coach a team of research scientists. We value what you do and how you do it.

Position Description

The Research Investigator will join the Discovery Pharmacology and In Vivo Biology Group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutic targets at the intersection of tumor genetics and tumor immunobiology. The successful candidate will possess expertise in mouse tumor models and in vivo pooled CRISPR screens and leverage these skills to drive in vivo target identification efforts. The successful candidate's team will also plan, execute and analyze preclinical in vivo studies, e.g. PK/PD and efficacy, interrogating our immuno-oncology and resistance biology portfolio.

The qualified candidate is a highly motivated, creative, and collaborative individual that possesses the ability to work across a highly matrixed environment and communicate effectively with multidisciplinary teams and key stakeholders. You are expected to leverage your experience and skills to train and coach a team of research scientists. We value what you do and how you do it.

Job Responsibilities and requirements

A PhD degree and postdoctoral training in cancer biology, or a closely related field, or a minimum of 2 years industry experience is required.

Demonstrated expertise designing and conducting in vivo CRISPR screens to identify novel targets is required.

In collaboration with colleagues in Oncology Discovery New Target Biology, design and execute in vivo pooled forward genetic screens to identify and validate new targets that modulate immune function and/or tumor cell biology.

In collaboration with Oncology Discovery colleagues, design and plan in vivo studies (including PK/PD and efficacy studies) to interrogate novel therapeutics modulating targets relevant to immune function and/or tumor cell biology

Develop a team of in vivo research scientists; train and mentor colleague

Collaborate with the Vet Sciences to ensure compliance with BMS and external animal welfare regulations.

Develop new animal models and incorporate new technologies to enable the exploration of novel therapeutics.

Communication of work, plans and progress using written and verbal communication in small and group settings

Extensive experience designing and conducting GEM or syngeneic tumor models and xenograft tumor models to explore tumor biology and immune-oncology.

Expertise with CRISPR, cell culture and ex vivo sample analysis, e.g. qPCR, ELISA

Experience in the development and utilization of multi-color flow cytometry to interrogate treatment mediated changes to the microenvironment of syngeneic tumors is a plus

Demonstrated capability to train others in in vivo and in vitro techniques

Demonstrated ability to integrate knowledge from literature

Excellent oral and written communication skills

Excellent interpersonal skills and ability to work in a fast-paced and dynamic environment is essential.

The ability to manage a small laboratory group is expected, including providing growth and development opportunities for direct reports.

This position will have up to 4 direct reports

This position is located in Cambridge, MA. There will be less than 10% travel.