Director, New Biologics Research
- Employer
- Santen, Inc.
- Location
- Emeryville, CA, United States
- Start date
- Jun 1, 2019
View more
- Discipline
- Regulatory, Science/R&D, Biotechnology, Research
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
At Santen, we're innovating therapies to improve the quality of life for patients worldwide. Our single focus in ophthalmology enables us to challenge unmet needs in the field-through passionate research, successful collaboration, and clarity of commitment. With over 130 years of investigative insight, Santen remains committed to the discovery, exploration, and development of ophthalmic therapies. As a global company, Santen is expanding to accommodate new and evolving initiatives in ophthalmic research, regulatory management, production, marketing, or distribution. Our clinical development network spans three continents, with centers in Europe, Japan, and the United States.
We are in search of top talent to help us meet our aggressive and important goals.
ABOUT THE POSITION:
This position is responsible for establishing new biologic entity pipeline for Santen. This position will specifically provide experienced, technical, and scientific leadership in the production of engineered mono and multispecific antibodies or novel protein scaffolds using state of the art technology for Santen's global development pipeline. Person will select lead candidate based on activity assays and developability assessments utilizing external organizations, ensure efficiency and attainment of project milestones, and coordinate and manage technical activities at the external organization. Initiates, presents and defends technical proposals and provides development updates to the management.
ESSENTIAL DUTIES AND KEY DELIVERABLES:
- Provide scientific, technical, organizational leadership for production of engineered mono- and multi-specific antibodies, from small to large scale, in support of research goals established for the new biological entities (NBE) in Global Pharmaceutical R&D; Assist in defining departmental strategy, especially with respect to NBE research goals
- Responsibility for Lead candidate selection, Developability Assessments, and Stable Cell Line development for IND enabling studies; Responsibility for the generation of new intellectual property in conjunction with these activities
- Identification, implementation, and resourcing of new technologies/applications/ external collaborations in support of research goals; Responsibility for integration with new technology providers. Participation in licensing and technology evaluation teams.
- Facilitate communication between groups within and outside Santen, including Global Disease Area Strategy, Global Non-clinical and Global Clinical SciencesParticipation in interdisciplinary internal Global R&D meetings and external meetings as required
- Recruit, retain, and develop high quality staff as necessary; Manage performance of direct and indirect reports, as necessary
- Ensure compliance with all required training, safety, regulatory, HR, and intellectual property activities and corporate policies
QUALIFICATIONS:
- PhD is Biopharmaceuticals, Molecular Biology, Chemical Engineering or Biochemistry
- Minimum of 10 years progressive work experience in the pharmaceutical industry.
- 2-4 years of Group/Project/External organizational management experience and hands-on development of antibody therapeutics in a drug discovery setting.
- Requires broad and thorough knowledge of production of antibodies and engineered molecules, developability or manufacturability assessments, stable cell line generation, and method development for purification of antibodies produced in mammalian/bacterial cell culture expression systems
- In-depth understanding of primary, secondary and tertiary protein structure and post-translational modifications.
- Hands on cell line development and experience in developing functional assays is a plus
- Requires the ability to communicate effectively by oral presentation, written technical reports, and scientific publications
- Ability to communicate scientific results internally and externally
- Ability to lead and participate in interdisciplinary teams, both locally and internationally
- Ability to propose, articulate, evaluate, and recommend new technology opportunities for licensing or partnering
- Ability to manage all aspects of the design, engineering, and generation of protein therapeutics (especially monoclonal antibodies)
- Ability to manage external collaborations with technology-based business partners in support of new biologics research goals
For more information about our company and the work experience, please visit www.santenusa.com
Company
Santen is a global pharmaceutical and medical device company focused solely on ophthalmology. We’re committed to serving serious unmet needs by developing innovative solutions that protect vision and, in turn, preserve quality of life for people around the world.
Santen USA, located in Emeryville, CA, is an important part of our ophthalmic research, development, and commercialization efforts worldwide and the home of our regional business teams. By leveraging our deep industry knowledge and a network of external partners, we aim to deliver game-changing therapies and make hope a reality for people facing vision impairment and loss.
Our deep roots start in Japan, Santen’s worldwide headquarters, where the company began in 1890. Since then, Santen has become an established leader in the Asian and European prescription ophthalmology marketplaces and continues to expand across global markets, including the United States. Today, Santen employs more than 4,000 people worldwide and sells specialty ophthalmic products in more than 60 countries.
With a clear focus on vision, we aim to deliver the highest quality products, to act with integrity, to earn the trust of our partners and customers, and to deliver sight-saving innovations to physicians and patients who are waiting for them.
- Website
- https://www.santenusa.com/
- Location
-
6401 Hollis Street
Emeryville, CA 94608
United States
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