Scientist (Protein Biochemistry- SPR/BLI)

Location
Tarrytown, NY, United States
Posted
Jun 01, 2019
Ref
16826BR
Required Education
Associate Degree
Position Type
Full time
Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking a biophysical chemist to provide analytical protein characterization through the use of cutting-edge biophysical technologies in the Protein Biochemistry group at Regeneron. The qualified candidate will be responsible for providing in-depth biophysical and biochemical characterization of therapeutic proteins to support mid-late stage development programs. The candidate is expected to take on a leading role in applying a diverse array of advanced biophysical techniques to deepen our knowledge of late stage biotherapeutic proteins and their inherent heterogeneity to support regulatory application.

Responsibilities
  • Independently designs and conducts protein biophysical and biochemical experiments; analyzes data to elucidate quality attributes of therapeutic protein candidates and/or products.
  • Provides biophysical support for both upstream and downstream functional groups; helps solve development problems in real-time.
  • Takes a leading role in late stage development support using affinity methods including optimizing kinetic assays using traditional and non-traditional reagents.
  • Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
  • Supervise Research Associate(s) conducting research and developmental work.
  • Participates in the general lab and instrument maintenance.

Requirements
  • Excellent written and verbal communication skills and the ability to work in a cross-functional team environment.
  • The candidate must demonstrate the ability to plan, design, implement and analyze laboratory experimentation to advance projects.
  • PhD in biophysical chemistry, molecular biophysics, or biochemistry with 0-3 years post-doctoral training in analytical protein characterization; experience in or collaboration with the biopharmaceutical industry is an advantage.
  • In depth knowledge of and demonstrated expertise operating SPR (Biacore) and/or BLI (Octet) instrumentation.
  • Deep understanding of principles of chemistry, biochemistry, as well SPR and kinetic assay experimental design.
  • Thorough understanding of affinity, avidity, and kinetics concepts.
  • Demonstrated ability to develop and troubleshoot novel kinetics assays using traditional and non-traditional protein reagents (mAb, scFv, Fc-Fusion, bi-specific antibodies, recombinant receptors, crude serum).
  • Experience in light scattering (static and/or dynamic) and spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins and/or size-based (e.g. SEC, CE-SDS, and/or AUC) and charge-based (e.g. icIEF, IEX) separation techniques is a plus.
  • Previous supervisory experience preferred.
  • A passion for science and innovation with a strong commitment to continual improvement and making significant contributions in a team environment.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.