Research Associate I/II, DNA Encoded Chemistry, Library Discovery

Nurix Inc.
San Francisco
May 29, 2019
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
We are seeking a talented and highly motivated scientist to join our Library Discovery team and help us augment our DNA encoded library collection. DEL synthesis requires a hybrid of techniques that are borrowed from chemistry environments: chemical reaction setup, LCMS analysis, SAR evaluation, split and pool library synthesis workflows, parallel reaction development, as well as from biology laboratories: aqueous buffer preparation, centrifuge use, ethanol precipitation of DNA, A260 DNA quantification, gel electrophoresis, bioanalyzer analysis, enzymatic DNA ligation. An exposure to some of these techniques is helpful in training into a DNA encoded scientist.

As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.

  • BS or MS in life sciences (ex. chemistry, biochemistry, biology) with 0-5 years industrial chemistry experience (years of relevant experience will impact level of hire)
  • Training in synthetic organic chemistry methods and analytical tools, in particular LCMS
  • Interest in optimizing chemical reactions for use in DNA encoded library synthesis
  • High level of creativity and productivity with strong problem-solving skills
  • High level of attention to detail and good organizational skills
  • Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.

Fit with Nurix Culture and Values
  • Strongly team-oriented; highly collaborative
  • Hands-on approach; resourceful and open to diverse points of view