Director, Regeneron Genetics Center- Biology

Known for its scientific and operational excellence, Regeneron is a leading science-based biopharmaceutical company that discovers, invents, develops, manufactures, and commercializes medicines for the treatment of serious medical conditions. Regeneron commercializes medicines for eye diseases, high LDL-cholesterol, atopic dermatitis and a rare inflammatory condition and has product candidates in development in other areas of high unmet medical need, including rheumatoid arthritis, asthma, pain, cancer and infectious diseases.

Summary
We are seeking a highly motivated Ph.D., M.D., or M.D./Ph.D. Director to lead RGC Biology programs dedicated to the characterization of the molecular function of genetic variants and candidate genes of interest to the RGC and Regeneron Therapeutic Focus Areas (TFAs). The successful candidate will report to the Vice President of Research (a co-founder and member of the leadership team of the RGC) and will work on developing projects around the following main categories:
(a) Developing methods for validating gene variants-phenotype links.
(b) Developing methods for testing computational predictions for Loss of Function as well as other types of functional variants.
(c) Modeling Genetics-driven human disorders and diseases in vitro and in vivo (with the focus being mostly on mouse models).
(d) Using the resulting models to understand mechanism of action of disease.
(e) Use of tool compounds, reagents, and systems to modulate gene/gene-product activity and get early readouts of function/phenotype.
(f) Communicating results and strategy to senior management and other stakeholders, such as the Therapeutic Focus Areas and outside Partners.

Responsibilities
The main impetus of the envisioned work is to extend the discoveries of the Regeneron Genetics Centers and its current Partners into the functional genomics and molecular biology space, and to partner with the Therapeutic Focus Areas (TFAs) and other internal and external Partners, particularly where there is an opportunity for the corresponding finding to inform drug development, repositioning existing and 'in pipeline' Regeneron drugs into new indications, or enabling drug development into a new disease space.
The successful candidate will lead a medium size group of Scientists, Research Associates, and Postdoctoral Fellows that will work on modeling mainly novel gene-phenotype links in vitro and in-vivo with the aim of providing a mechanistic understanding of how variants affect the properties of the corresponding gene product and drive a phenotype. In vivo studies will leverage Regeneron's unique and high throughput capabilities with genetically modified mice (to be generated collaboratively with VelociGene®). In addition to her/his leadership role, the successful candidate is expected to coordinate this effort with internal and external collaborators, integrate with other Regeneron programs and collaborate in generating in vivo models of disease. She/He should be able to work in a fast paced, collaborative, interdisciplinary environment, have good communication and organizational skills and be able to quickly learn and apply new techniques and methods.

The Director will:

• Lead a team of Scientists and Research Associates that design in vitro and in vivo studies and analyze the resulting data.

• Coordinate with Regeneron Scientists to generate models of disease.

• Survey the literature and conferences for discoveries and findings from the broader genetics/molecular and cellular biology communities in order to integrate such findings into study opportunities and considerations internally.

• Organize projects and prepare presentations.

• Communicate and report study findings, analyses and future directions with senior leadership, administration, and collaborators.

• Coordinate with Regeneron and external collaborator scientists to integrate findings and analyses into new and existing programs.

• Take the lead and/or participate in the writing of manuscripts and coordinating their publication.

• Contribute to management of group goals, as well as individual development goals.
Requirements
This position requires a minimum of a PhD or equivalent degree in the area of biology or life sciences, with 10+ years of post-graduate research experience related to Molecular Biology and/or Molecular Genetics, as well as experience in running a research lab; the latter is key.

This experience should include:

• A proven track record in running a research lab.

• A Strong background in molecular biology and characterization of protein function.

• Experience with molecular characterization and other functional studies geared towards following up genetic association analysis.

• Familiarity with clinical genetics and genetic models of disease.

• Proven data analysis skills.

• Computer literacy and Microsoft Office competence (Word, Excel, PowerPoint).

• Good organizational skills.

• Good leadership skills.

This is an opportunity to join our select team that is already leading the way in the Pharmaceutical/Biotech industry. Apply today and learn more about Regeneron's unwavering commitment to combining good science & good business.

To all agencies: Please, no phone calls or emails to any employee of Regeneron about this opening. All resumes submitted by search firms/employment agencies to any employee at Regeneron via-email, the internet or in any form and/or method will be deemed the sole property of Regeneron, unless such search firms/employment agencies were engaged by Regeneron for this position and a valid agreement with Regeneron is in place. In the event a candidate who was submitted outside of the Regeneron agency engagement process is hired, no fee or payment of any kind will be paid.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.