Scientist II/ Senior Scientist I, Tau Biology in Neurodegenerative Diseases

Employer
AbbVie
Location
Cambridge, MA, US
Posted
May 27, 2019
Ref
1901485
Required Education
Bachelors Degree
Position Type
Full time
AbbVie has established the Foundational Neuroscience Center (FNC) in Cambridge, MA to investigate the fundamental biological mechanisms and to develop therapeutic interventions for neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The Tau Biology group is seeking a highly motivated applicant with prior experience and expertise in cell biology and molecular neuroscience for target validation and assay development in neuroscience. The Scientist will support a project leader in performing molecular and multiplexed image-based screening studies to discover small molecules/biologics interfering with tau aggregation/propagation in neurons.

Key Responsibilities Include:

  • Expert in design and construction of gene expression cassettes
  • Molecular cloning and designing of mRNA, miRNA, shRNA, CRISPR/cas9 for knockin and knockdown constructs
  • Expert in primary neuronal cultures. Experience with human iPSC-derived neurons is a plus but not required
  • Experience in molecular neuroscience fields such as neurodegenerative diseases, learning and memory, or neuropharmacology
  • Lead and or / assist in writing SOPs
  • Work efficiently to meet deadlines, well with team members, and contribute to a healthy and fast-paced environment
  • Excellent communication - both in writing and presenting results with direct report and team, analytical, and interpersonal skills
  • Read and apply relevant scientific literature
  • Experience with super-resolution, high - content, high throughput using robotic-assisted imaging is a plus but not required


Position will be hired based on level of experience.
  • BS, MS, or PhD in Molecular Neuroscience or related field with typically 7+ (BS), 5+ (MS) or 0+ (PhD) years of experience. Pharmaceutical experience preferred.
  • Proficiency with standard cell biology, genetic manipulation, molecular and microscopy methods.
  • Expertise in generating plasmids and cellular assays for target validation and high throughput screening
  • Molecular techniques including cloning, qPCR, RT-PCR, DNA, RNA isolation
  • Familiarity with plate readers and/or high content imaging / familiarity with neuroanatomy is plus but not required.
  • Comfortable using computer programs such as Microsoft, PowerPoint, Google Docs, Microsoft Excel
  • Highly motivated, detailed oriented, curious of the science, and desire to learn to novel neuroscience techniques.
  • Demonstrate critical thinking, independence, clear scientific writing & verbal communication skills and precise record keeping
  • Strong organizational skills that facilitate planning, multitasking and working within timelines.

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.