Senior Scientist I/II, Proteostasis

The AbbVie Foundational Neuroscience Center (FNC) in Cambridge, MA was established to investigate the biological mechanisms underlying neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. AbbVie scientists are using this understanding of disease processes along with state-of-the-art technologies to develop transformative treatment options for patients.

The Proteostasis Biology Area is pursuing therapeutic approaches to modulate the cellular protein quality control mechanisms that regulate protein misfolding and aggregation. We are seeking a highly motivated applicant with prior expertise in drug development for neurodegenerative disorders. The senior scientist will be responsible for pursuing novel biology, building high throughput assays, supporting small molecule and genomic screens, and leading multi-disciplinary teams to advance novel compounds to the clinic.

Key Responsibilities:

• Develop, optimize and execute relevant experimental approaches to support drug discovery & development programs in the field of Alzheimer's and Parkinson's disease research
• Generate rational hypotheses; plan and execute laboratory experiments with proper controls; collect robust data sets and apply statistical analyses; interpret and present data before project teams
• Develop and execute biochemical and cell-based assays to validate novel targets in the proteostasis area
• As a member of an interdisciplinary team, work together with cellular and molecular biologists, in vivo pharmacologists and medicinal chemists, also across global research sites
• Present research activities/results at internal and external meetings, and publish in peer-reviewed journals

Position will be hired based on level of experience.

• PhD in neuroscience or closely related field with 0-4+ years of industry experience leading drug discovery programs (high throughput screening, hit-to-lead, lead-optimization); MS degree and 8-10+ years of experience or BS degree and 10-12+ years of experience
• Specific expertise in proteostasis pathways and the biology of neurodegeneration
• Proficiency with standard cell and molecular biology, biochemistry, enzymology and neuroscience techniques including iPSC-derived neuron culture, gene transfer methods, microscopy and high-content imaging, protein detection & quantification (such as ELISA, MSD, plate readers), and enzyme kinetic assays
• Proven ability to design, execute and interpret critical experiments independently and to advance scientific understanding
• Strong record of scientific accomplishment as demonstrated by publication in high-impact journals
• Excellent written and verbal communication skills
• Strong interpersonal abilities
• Commitment to teamwork with a penchant to work productively and creatively in a multi-disciplinary environment
• Strong organizational skills that enable multitasking and working within timelines