Research Associate I/Electron Microscopist

Frederick, MD, USA
May 26, 2019
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide electron microscopy, protein characterization, protein expression, optical microscopy and genetics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR). CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise

  • Provide technical advice to investigators on sample preparation, and data collection
  • Operate TEM microscopes, specifically Titan Krios, Talos Arctica and Talos L120C; task will include loading samples, screening, and performing high-resolution data collection for single particle studies as well as cryo-electron tomography
  • Manage maintenance for the Talos Arctica as well as associated instruments (T12, Talos L120C)
  • Interact closely with colleagues within the CMM

  • Possession of a Bachelor degree from an accredited college or university according to the Council for Higher Education Accreditation in Biological Sciences, Structural Biology, or related discipline. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the educational requirements, a minimum of two (2) years of experience with Cryo-EM, Cryo-electron tomography, and high resolution single-particle analysis
  • Must be detail-oriented and able to manage multiple projects simultaneously.
  • Strong laboratory skills
  • Must be able to obtain and maintain a clearance

  • Experience with negative stain and other specimen preparation techniques for EM, as well as cryo-TEM
  • Use of TEM microscopes, Titan Krios, Talos Arctica, T12, T20, Talos L120C.
  • Manage sample preparation for cryo-EM studies as well as for negative stain screening.
  • Maintenance of TEM microscopes.

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)