Research Associate I

Frederick, MD, USA
May 26, 2019
Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.


The general responsibility will be to provide Center for Cancer Research (CCR) at the NCI with excellent support in proteomics and protein analysis using mass spectrometry.
  • Analyze samples for CCR investigator and communicate with them regarding experimental set up and data interpretation
  • Using broad sample processing method for mass spectrometry analysis
  • Daily operation of different orbitrap mass spectrometers
  • Use different HPLC methods for prefractionation of samples in preparation for mass spectrometry analysis
  • Perform variety of raw mass spectrometry data processing using Proteome Discoverer and other open source and proprietary software, pertain to extracting information from mass spectrometry data
  • Cell culture to grow cell in preparation for variety of experiments, such a protein complex isolation and quantitative global proteomics
  • Western blotting for monitoring protein expression and validating protein interaction
  • Keep detailed record of all experiments and lab activities for quality purposes and future publications

  • Possession of a BS degree in chemistry, biochemistry or related fields from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the educational requirements a minimum of 2 years post-graduation laboratory experience in biochemistry, chemistry or related fields.
  • Must be able to obtain and maintain a clearance

  • Theoretical and hands on experience using mass spectrometers to analyze chemical and/or biological molecules/samples
  • Some programming and data analysis skills are desirable

  • Basic laboratory techniques, such as different sample preparations methods, western blotting, cell culture and other relevant laboratory procedures

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)