Research Associate, Vivarium

Employer
AveXis Inc.
Location
San Diego, CA, US
Posted
May 24, 2019
Ref
2019-3368
Discipline
Science/R&D, Research
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Overview

Ready to join a team committed to moving gene therapies into the clinical and commercial settings for patients and families devastated by rare neurological genetic diseases? AveXis is advancing cutting-edge science to treat rare and life-threatening genetic diseases starting with our clinical-stage, proprietary gene therapy candidate, AVXS-101 (ZOLGENSMA®). We are in the midst of an incredible journey and are looking for passionate individuals to join us on this important mission.

AveXis, Inc., a Novartis Company , is a clinical-stage gene therapy company, dedicated to developing and commercializing novel treatments for patients suffering from rare and life-threatening neurological genetic diseases. Our initial product candidate, AVXS-101, is our proprietary gene therapy product candidate currently in development for the treatment of spinal muscular atrophy, or SMA, Type 1, the leading genetic cause of infant mortality, and for the treatment of SMA Type 2. The U.S. Food and Drug Administration, or FDA, has granted AVXS-101 Orphan Drug Designation for the treatment of all types of SMA and Breakthrough Therapy Designation, as well as Fast Track Designation for the treatment of SMA Type 1. In addition to developing AVXS-101 to treat SMA Type 1 and Type 2, we also plan to develop other novel treatments for rare neurological diseases, including Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene.

The vivarium position in research and development will be responsible for animal care and handling including breeding, dosing, executing in vivo experiments under supervision of scientists, and tissue collection related to existing and pipeline products.

Responsibilities

  • Performs certain basic tasks necessary for the husbandry and study of rodent models of disease such as animal identification by marking, breeding, weaning, and collection of tissue samples for DNA or RNA analysis.
  • Work interactively with research and development team to validate, characterize, and distribute mouse models that directly address drug discovery and program validation.
  • Under close supervision, responsible for executing, tracking, and managing genotyping.
  • Interfacing on a regular basis with lead scientific staff to organize, schedule and execute experimental work.
  • Examine data and prepare technical reports, summaries, protocols and quantitative analysis, ensuring experiments are well documented and comply with regulatory requirements.
  • Maintain and ensure safe laboratory environment and work practices. Follow standard operating procedures (SOP) and IACUC protocols. Help to maintain laboratory and order common supplies.
  • Ability to work collaboratively across a dynamic scientific environment, therefore excellent communication skills, both written and verbal, and strong interpersonal skills.
  • Additional activities as needed.


Qualifications

  • Bachelor's degree from an accredited college/university in a field related to biomedical research, neuroscience, animal behavior or animal sciences. Equivalent experience may be accepted.
  • Experience in rodent handling is necessary.
  • Proficiency with standard in vivo techniques in rodents, including dosing and sampling routes (e.g., po, ip, sc, iv dosing; cardiac bleeds; necropsy and organ/tumor harvest) is required. Experience with transcardiac perfusion preferred.
  • Experience characterizing rodent models of various human diseases is preferred.
  • Previous industry experience is preferred but not required.
  • Excellent oral and written communication skills.


The level of this position will be based on the final candidate's qualifications.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

AveXis is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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