Amgen

Postdoctoral Fellow - Computational/Systems Biology

Employer
Amgen
Location
Cambridge, MA, US
Posted
May 23, 2019
Ref
R-43797
Discipline
Science/R&D, Biology
Required Education
Doctorate/PHD/MD
Position Type
Full time
The Amgen Postdoctoral program is committed to providing future scientists with an enriching environment to inspire innovation that will contribute to the development of human therapeutics.

Dr. Ramsey Saleem in the Attribute Sciences department at Amgen, Inc. is seeking a highly motivated Postdoctoral Fellow in the area of Computational Modeling.

Amgen is seeking a computational biologist to assist in efforts to generate models of the cellular subsystems that are involved in production of biologics in CHO cells. Amgen's interest in this approach results from an applied, medically relevant problem, with significant financial consequences. We seek to understand our system at a level whereby we can systematically predict conditions which result in cells producing high levels of therapeutic proteins with the desired physical attributes. To this end we seek individuals to assist us in.
  • Generate models of the cellular subsystems that are involved in production of biologics in CHO cells. These include but are not limited to:
    • Golgi mediated N-linked glycosylation
    • Transcription - chromatin remodeling, RNA processing and export
    • Translation - ribosome assembly, ribosome progression
    • Metabolic Flux Balance
  • Optimize model parameters and refine to generate models with predictive value as done with the Golgi mediated N-linked glycosylation
  • Link the models together so that the outputs from upstream subsystems provide inputs for downstream subsystems.
  • Use in-house data to constrain the models and provide Amgen specific solution spaces for the models.


The postdoctoral position is for 2 years with the option to extend for an additional year.

Basic Qualifications

PhD at the time of appointment

Preferred Qualifications

Demonstrated skill in the development of mathematical models of biological processes

Experience in programming

Expertise with statistics

Candidates with a significant understanding of the biological underpinnings of protein production

Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.