Bristol-Myers Squibb Company

Research Scientist II Ex-vivo Models

Location
Cambridge, MA, United States
Posted
May 23, 2019
Ref
R1514482
Required Education
Bachelors Degree
Position Type
Full time
Bristol-Myers Squibb R&D is a science-driven, passionate organization determined to discover, develop and deliver medicines that have the potential to transform the lives of patients and establish new standards of care in areas of high unmet need. Patients' needs and scientific discovery are our driving force. The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will position our scientific team in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. Our scientists will focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology therapies. These are significant challenges that will require innovative solutions from the biopharma, biotech, and academic communities.

Roles and Responsibilities

We are seeking a Research Scientist, who has experiences in cell biology and immune-oncology. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to support and advance translational research programs. The candidate must have a technical background in cell culture, flow cytometry and immunology assays. Additional qualifications include a deep understanding of 3D cell culture, prior experience working with primary tissues, and hands-on experience processing tissues for flow cytometry and downstream assays.

Qualifications / Essential Skills

A B.S. with a minimum of 5 years of experience, or an M.S. with a minimum of 3 years of academic/industrial experience with a strong scientific background and research experience in immune-oncology is required.

Develop innovative scientific methodologies and approaches to enhance research productivity.

Develop and apply complex in vitro assays including spheroids, matrices, organoids and microfluidic models to advanced 3D tumor spheroid and co-culture studies.

Hands-on experience and practical knowledge in cellular assays, including viability/cytotoxicity assays, migration, and cytokine secretion in combination with imaging technologies on organoids to support drug programs.

Specific experience with processing of biological samples to extract primary cells, especially from solid tumors or epithelial tissue types. Molecular characterization of patient tumor, and organoid models at bulk and single cell level.

Familiarity with standard scientific protocols and techniques such as confocal microscopy, Western blotting, ELISA, PCR, high-throughput imaging, FACS are highly desirable.

We follow the science and we'll continue to invest in translational medicine research, deepen our understanding of disease biology and uncover insights about predictive biomarkers with the ultimate goal of making precision medicine a reality.