Liquid Biopsy Senior Research Scientist

Bristol-Myers Squibb R&D is a science-driven, passionate organization determined to discover, develop and deliver medicines that have the potential to transform the lives of patients and establish new standards of care in areas of high unmet need. Patients' needs and scientific discovery are our driving force. The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will position our scientific team in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities. Our scientists will focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology therapies. These are significant challenges that will require innovative solutions from the biopharma, biotech and academic communities.

Role / Responsibilities

We are seeking a talented research scientist to join our Translational Research group in our new state-of-the-art facility in the heart of Kendall Square. This position will provide an opportunity to develop new approaches and technologies to interrogate biomarker of resistance to immunotherapy in liquid milieus. The qualified candidate is a motivated, interactive, and creative individual who possesses the ability to work across a matrixed environment to advance translational research. This is a laboratory-based position, which will primarily focus on new technology development, but will also include routine lab work, including sample processing, data acquisition, and analysis. To be successful in this role, the candidate must have a strong background in new technology development with a demonstrated track record of success in employing new approaches to address biologically complex problems. Prior experience in developing sequencing approaches and technology for cfDNA, single cell, FFPE, and TCR is a requirement. A background in biomarker research, working with clinical samples, and oncology drug development is a plus. To be at the forefront of elucidating and overcoming resistance to immunotherapies, we encourage aspiring scientists who are passionate problem solvers that thrive clinically relevant challenges, to consider this unique opportunity.

Qualifications / Essential Skills

BS with 5-7 years or MS with 3-5 years of post-graduate experience in an academic or industrial setting

Prior experience in new technology development, implementation, and trouble-shooting

Experience isolating DNA from plasma, circulating tumor cells, and sorted cells

Strong background in sequencing from single cell, circulating tumor cells, sorted populations, and FFPE material

Familiarity with laboratory inventory management system

Prior experience working with cell lines and primary human tissue samples; experience working with blood and blood products is plus

Prior biomarker experience, working with clinical samples, and oncology drug development is a plus

Academic background in molecular biology, cell biology, cancer biology, genetics, and/or immunology is required

Excellent interpersonal skills and ability to communicate effectively, written and orally, within the team and larger organization

We follow the science and we will continue to invest in translational medicine research, deepen our understanding of disease biology and uncover insights about predictive biomarkers, with the ultimate goal of making precision medicine a reality for more patients.