Bristol-Myers Squibb Company

Director, Lead Evaluation Oncology

Location
Princeton, NJ, United States
Posted
May 23, 2019
Ref
R1514484
Discipline
Science/R&D, Oncology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Summary

We are seeking a highly motivated and innovative leader who will lead a core function, Lead Evaluation, located in Princeton, NJ to support and accelerate Oncology Drug Discovery Portfolio at BMS. The group will work closely with Oncology Biology, Translational Medicine, Discovery Chemistry and Protein Therapeutics with a mission to discover and develop innovative Immuno-oncology and Oncology pipelines. This leader will be a member of the oncology portfolio governance team and will be expected to represent Leads Discovery and Optimization (LDO) capabilities to align with the portfolio needs and project priorities. The successful candidate will join LDO leadership team and have a direct reporting relationship with the Vice President of LDO.

Candidate Specifications

Knowledge and demonstrated a track record to develop and validate high throughput assays (biochemical, cellular, biophysical, other) on cost effective and up-to-date technical platforms,

A good understanding of cell signaling in cancer biology and immunology and broad experiences in Oncology drug discovery research

Broad experiences in assay trouble shooting and exploration of new technology platforms to enhance the infrastructure for discovery program support

Strong ability to manage across projects across functional lines and geographic sites/locations

Identify and/or innovate new technologies or functional line projects that bring value and efficiency to BMS

Represent technical and scientific ideas, as well as project progress/updates to preclinical research teams, IORB portfolio governance, LDO colleagues and leadership/governance

Contribute to the development of clinical assays derived from preclinical flowchart assays and contribute to the development of regulatory documents (IND, IB, etc),

Strong collaborative and written/verbal communication skills and a positive attitude to interact with multiple stakeholders (e.g. therapeutic area teams, Chemistry and Biology leads and outside vendors)

Scientific leadership both at the bench and at data analysis.

Requirements

PH. D with minimal 10 years of scientific experience in immunology or tumor oncology.

Experiences in managing a high performance team

Comprehensive technical expertise in developing and performing diverse in vitro immunoassays with whole blood, T-cells, B-cells, monocytes and macrophages.

Hands-on experience with phenotypic screens

Hands-on experience with confocal imaging, flow, HTRF, qPCR, and cell based assays

Hands on knowledge of contemporary automated platforms used for hit identification and lead optimization instrumentation would be very valuable.

Proficiency in designing 384 and 1536 well assays and adept with robotics and lab automation

Broad knowledge in compound screening strategy is critical

Strong hands on experience in Oncology Lead Optimization programs

Technology development and implementation experience will be very useful

Work with cross-functional project teams to implement automated solutions for assay automation

Demonstrated excellence in both written and oral communication and a strong desire to lead in cross functional teams to establish productive collaborations across large portfolios

A strong desire to succeed in cross functional teams to establish productive collaborations