Senior Research Investigator (Single Cell Genomics)

Senior Research Investigator (Single cell Genomics- BMS-Cambridge) R1508144

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

We seek a highly motivated, detail-oriented leader with broad experience in application of single cell genomics tools in solving complex biological problems. Experience implementing or optimizing methods for single cell RNA-seq, single cell DNA -seq or CITE-seq approaches preferred. The successful candidate will have broad experience in Next Generation Sequencing (NGS) work flows and associated analysis methods. Proficiency in various genomics methods and workflows is essential.

The individual will be part of the Genomics group at our Cambridge site, working as part of an integrated team dedicated to understanding mechanisms of immune resistance in cancer. Primary responsibilities include various single cell genomics-based assay development and implementation in support of drug discovery programs, novel genomic method development and optimization, establishing outreach and collaboration across the Cambridge area, leveraging its vibrant genomics ecosystem.

Responsibilities:

• Play a key role in the method development for high throughput single cell RNA and DNA and CITE-Seq approaches.
• Provide genomics assay support for various programs.
• Play a role in optimizing and developing new and existing NGS protocols to suit needs.
• Manage Research scientists to deliver data to investigators
• Genomics data interpretation and presentation to key stake holders
• Maintain lab notebooks, compile data, and detail written experimental instructions, particularly in areas involving new technology and/or novel experimental approaches.

Requirements:

• The successful candidate will have Ph.D. in Molecular/Cell Biology or Genetics or Biochemistry with at least 5 years or M.S in Molecular/Cell Biology or Genetics with at least 8 years of relevant scientific lab experience with emphasis on Next Generation Sequencing (NGS) work flow and other genomics methods.
• Robust experience in NGS work flow including library generation and relevant method development.
• Broad experience in advanced Cell and Molecular Biology technique is essential.
• Experience in various single cell genomics is required.
• Experience in working with FFPE and other clinical sample handling preferred.
• Detail oriented and effective communicator.
• Expertise in cell separation technologies such as FACS/Microfluidics a plus but not essential.
• Strong focus, motivation, and commitment to hands-on lab work.
• Ability to trouble shoot and make independent decisions regarding experimental details
• Extensive people and project/matrix team experience, with demonstrated ability to work effectively within multidisciplinary teams.
• Flexibility to accommodate to rapidly changing priorities and deadlines