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Scientist 1 or 2 - LC/MS Bioanalysis

Employer
BioMarin Pharmaceutical Inc.
Location
San Rafael, CA, United States
Start date
May 21, 2019

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Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

Title: Scientist 1/2, BARD Employee Type: FTE Location: San Rafael, CA Critical to the success of each new therapeutic, the BioAnalytical R&D group develops and validates novel assays to measure pharmacokinetics, immunogenicity and biomarkers. We are searching for an experienced bioanalytical scientist to develop and validate assays that will impact non-clinical and clinical studies with innovative new technologies and methodologies. This position offers a unique career opportunity to work on the entire spectrum of a product lifecycle, from early non-clinical work through all stages of clinical development, including post-marketing work. The successful candidate will interact with Research and Clinical Scientists, PK scientists and toxicologists to advance our most promising pipeline molecules for rare diseases. You will be in a position to apply various platforms that accelerate drug development, while maintaining a critical eye on assay quality and maintaining regulatory standards. Specifically, we are looking for a motivated and driven bench scientist with ≥2 years of LCMS assay development experience, who has a track record for building assays for small molecules, proteins and/or oligonucleotides (drugs, metabolites, biomarkers) that have been critically reviewed by regulatory agencies.

This Scientist position will report to a Director in BioAnalytical R&D, and will have the opportunity to influence the evolution of the BioAnalytical Sciences department in a growing biotech company.

RESPONSIBILITIES

Develop a variety of analytical methods to detect drug, metabolites and biomarkers in biological matrices. Techniques may include (but are not limited to) mass spectrometry, HPLC/UPLC, and proteomics. Present results, conclusions, and implications to BioAnalytical R&D group. May function as the primary Bioanalytical R&D interface to other departments regarding a designated project and present results to project teams. Develops new techniques, or brings in new technology from the outside, to enhance the analytical capabilities of the group. Prepares SOPs and other documents such as validation protocols, validation reports, and data reports for testing results. Share responsibility for lab management duties. Participates and presents data as a member of BioAnalytical teams, and shares responsibility for project milestones. May serve as Principal Investigator for GLP assays, participate in audits and inspections, and adhere to regulatory compliance standards. Independently carry out the aforementioned tasks and plan, implement, and complete significant projects with little supervision. Participates in scientific meetings and produces original peer-reviewed publications. Other duties as assigned.

EDUCATION

Preferred: Doctorate (Ph.D.) degree in Biology, Chemistry or related fields. Established field of expertise in protein chemistry, oncology, immunology, metabolic disease or similar.

EXPERIENCE

At least 2 years of hands-on experience of using the LCMS platform in a biological or biochemical field including ≥1 year of quantitative analytical method development. GLP experience is preferred. Ability to solve moderately complex issues independently. Excellent verbal and written communication skills. Ability to use computer effectively for data analysis.

~BIO

Company

BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.

Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.

Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.

Company info
Website
Location
California
United States

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