Research Scientist, In Vivo Research & Engineered Cell Biology

Location
92121, San Diego
Salary
$35-45/hr
Posted
May 17, 2019
Required Education
Masters Degree/MBA
Position Type
Full time

Our client is currently focused on utilizing its proprietary E-CEL technology as a direct therapeutic product for improving Hematopoietic Stem Cell Transplants (HSCTs), as well as offering a novel therapy for the regeneration of damaged tissues resulting from both acute and chronic disease. 

Research Scientist, In Vivo Research & Engineered Cell Biology

Position Role & Responsibilities:

  • Conduct pre-clinical in vivo studies, some requiring microsurgery, which test our pre-clinical engineered cell product candidates
  • Analyze data collected from in vivo studies performed
  • Participate or lead in design of in vivo studies
  • Conduct and analyze 2-D and 3-D engineered cell culture and assay experiments relevant to engineered cell product candidates
  • Works collaboratively with fellow AB team members, especially with the AB Research Team and the AB Project Management Team

Education/Requirements:

  • Master’s degree or PhD in cell biology, molecular biology, biochemistry, immunology or related field and 5 or more years post-graduate hands-on laboratory experience (post-doc or industry experience) covering both in vitro and in vivo work.
  • Enjoys a fast-paced environment where data-based changes are a constant and where proactive ‘can do’ attitude, sense of urgency and friendly personalities are prized.
  • A track record of the ability to learn new in vivo surgical and modelling techniques is essential
  • Possesses skills related to wet-lab cell-therapy translational research
    • Various cell culture techniques, cell sorting, flow cytometry, qPCR, fluorescent microscopy, antibody assays, intra-cellular signaling detection).
  • A successful candidate must have extensive hands-on experience in performing in-vivo animal modelling work for various potential indications.
  • Previous experience with the following in vivo procedures:
    • Tissue extraction and dissection, IV injection (tailvein, jugular, retro-orbital) and surgical proficiency in murine models (not limited to a specific area: e.g. intratracheal administration, partial hepatectomy, partial pneumonectomy, vascular ligation and/or thrombosis, gastrointestinal and/or vascular anastamoses, etc)

Additional Desired Skills and Knowledge.

  • Applicants with experience in various micro-surgical procedures in murine models. The applicant’s ability to not only perform such surgical procedures, but also demonstrate knowledge and experience in designing such in vivo experiments would be highly regarded.
  • Applicants with expertise in organ regeneration modelling related to inflammatory and autoimmune disease and injuries would also be preferred.
  • Preference for candidates with experience in the fields of tissue regeneration and/or microvascular biology and vascular niches.
  • Demonstrated expertise in translational in vivo cellular biology involving research and/or product development of cell therapy product is highly desired.