Research Associate/Sr Research Associate - Genomic Toxicology

Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, was founded in 1989 and was purposely designed to create a better, more efficient drug discovery platform, establish a new innovation-centered business model, and maximize the value of every medicine created and get it to the people who need it most as quickly and as efficiently as possible.

With the RNA molecule as the basis of our novel drug discovery platform, we are targeting an unprecedented range of therapeutic areas. Our antisense therapies are disrupting diseases and changing their course—from the rarest of conditions, to those that impact millions of people. We currently have three commercial products and more than 40 potentially transformative medicines in our pipeline designed to treat a broad range of diseases.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.

Research Associate/Sr Research Associate - Genomic Toxicology​

 We are currently seeking a highly qualified, highly motivated individual for the position of Research Associate/Sr Research Associate in our Research Toxicology group who shares the passion of our core principles and culture. We are seeking a technically proficient individual with a broad base of skills, to execute nucleic acid (RNA-seq, WGS, exome sequencing) and protein-based assays (e.g. ELISA), develop/perform cell-based toxicology screening assay, and assist in conducting rodent studies.  These studies will inform broad platform behavior across chemical classes, organs and interspecies relationships.  The ideal candidate will be working in the laboratory as an integral part of the Toxicology team and in collaboration across multiple disciplinary areas to help us understand and avoid tolerability issues of antisense oligonucleotides. So, join us and experience our unique culture while developing and expanding your career.

REQUIREMENTS:

• The successful candidate with a background in Molecular/Cell Biology or Genetics, will have B.S. with 5 years of relevant experience or M.S with at least 3 years of relevant scientific lab experience with emphasis on Next Generation Sequencing (NGS) work flow and cell culture.
• Demonstrated experience with next-generation sequencing methods:
  • From experimental design to library preparation for various RNA-seq approaches, WGS, and exome sequencing and familiarity sequencing instrumentation (NovaSeq, NextSeq).
  • Experience in single cell genomics would be a plus.
  • Some programming and scripting abilities in languages such as Python to use for genomic data analysis is highly desirable.
• Solid experience with mammalian cell culture with a focus on primary cell culture with a focus on immunobiology. Some experience with cell separation technologies such as FACS, microscopy (confocal, laser-capture micro dissection) would also be highly desirable.
• Solid experience with common molecular biology techniques such as RT-PCR, protein work (western, ELISA, immunoprecipitations...) with an ability to optimize new techniques independently.
• Some experience with rodent handling is preferred (dosing through various route of administration, necropsy…).
• Demonstrated ability to critically interpret experimental results and independently identify next steps.
• Excellent oral and written communication skills.
• Self-starter who is highly motivated and not afraid to take risks.
• Ability to be productive and successful in an intense work environment.

Excellent salary and benefits package offered.

Please visit our website, www.ionispharma.com, for more information about Ionis.

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.