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Scientist I/II, Preclinical Pharmacology

Employer
Nurix Therapeutics
Location
San Francisco
Start date
May 17, 2019

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Discipline
Science/R&D, Biotechnology, Pharmacology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay
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Job Details

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, inflammation, and immuno-oncology. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, inflammatory disease models, and immune cell profiling by flow cytometry. This role will support novel drug development projects from early lead optimization through clinical candidate selection. Duties include planning, execution and analysis of in vivo experiments, management of work within the preclinical pharmacology team, and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate must be self-driven, highly organized, and enjoy working in a creative and dynamic team environment.

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient's lives with first-in-class therapies, please consider applying.

Qualifications
  • Ph.D. in pharmacology, immunology, cancer biology or a related field. Scientist II level requires similar background with 3+ years of industry experience.
  • Expertise in oncology, immuno-oncology, inflammation and in vivo models of disease
  • Expertise with flow cytometer-based profiling of immune cells required
  • Expertise in small molecule drug development and PK/PD assay technologies
  • Expertise with hit-to-lead optimization and establishment of PK/PD relationships
  • Proven ability to manage projects, sub-teams, external collaborations, and CROs
  • Knowledge of transgenic model generation and phenotypic characterization desired
  • Writing preclinical reports or sections of IND a plus
  • Requires excellent communication and presentation skills


Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info
Website
Phone
415-660-5320
Location
1700 Owens Street
Suite 205
 San Francisco
California
94158
US
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