Scientist, Cancer Biology

Location
Bothell, WA, United States
Posted
May 12, 2019
Ref
o5aR9fwZ
Required Education
Doctorate/PHD/MD
Position Type
Full time
Summary:

Seattle Genetics is a biotechnology company focused on developing and commercializing innovative, empowered antibody-based therapies for the treatment of cancer. We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells.

We are seeking a highly talented and experienced scientist with a strong cancer biology and/or cell biology background to join the Cell Biology team. The successful candidate will lead independent efforts to advance the company's drug research pipeline.

Responsibilities:
  • The candidate is expected to apply leading edge in vitro and in vivo methodologies to evaluate activity and mechanism(s) of antibody therapeutics, small molecule chemotypes, and ADCs
  • Identification and validation of tumor antigens suitable for targeting specific cancer subtypes
  • Generation and characterization of monoclonal antibodies and selection of small molecule payloads for novel ADC therapeutic development
  • Evaluate external technologies and partnership opportunities to support, build, and diversify the therapeutic pipeline
  • Present data at research project team meetings and seminars to drive recommendations for drug discovery and/or development decisions


Requirements:
  • Ph.D. in Cancer Biology, Cell Biology, Biochemistry, or related fields in cancer research. Ideal candidate will have 2+ years of biotechnology or pharmaceutical industry experience in cancer drug discovery (including industry post-doc)
  • Experience conducting research into either small molecule or protein biologic drug discovery and mechanism(s) of action of cancer drugs in a team environment
  • Demonstrated understanding of oncogenic signal transduction pathways involved in regulating cell growth and differentiation, malignant transformation, and drug resistance
    Working knowledge of flow cytometry and other assays to measure receptor-ligand interaction, biochemical methods to interrogate signaling pathways, as well as utilization of lentiviral and CRISPR/Cas9 gene editing methodologies
  • Experience in the design and interpretation of cell line xenograft, patient derived xenograft (PDX), and syngeneic model oncology studies to measure in vivo antitumor activity of small molecule and/or antibody-based therapeutics is preferred
  • Excellent skills in written and oral communication, organization and multitasking, and working in a collaborative and cross-functional research environment
  • A strong scientific publication record


As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.

Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.