Eli Lilly and Company

Research Scientist-Bioassay Development

Location
Greenfield, IN, United States
Posted
May 10, 2019
Ref
49190
Required Education
Doctorate/PHD/MD
Position Type
Full time
Elanco is a global animal health company that develops products and knowledge services to prevent and treat disease in food animals and pets in more than 90 countries. With a 64-year heritage, we rigorously innovate to improve the health of animals and benefit our customers, while fostering an inclusive, cause-driven culture for more than 5,800 employees. At Elanco, we're driven by our vision of food and companionship enriching life - all to advance the health of animals, people and the planet. Learn more at www.elanco.com.

Responsibilities
The Research Scientist will use their skills and knowledge in Assay Development and Cell Biology to plan, organize and conduct assays on biopharmaceuticals and vaccines. The incumbent will participate in testing and analysis on therapeutic/preventative molecules in the Elanco Research Laboratories by designing novel cell-based bioassays. This position will be responsible for designing and validating a panel of assays to evaluate biopharmaceutical activity, potency, and/or binding kinetics. This position will also design assays to interrogate the fundamental properties of veterinary antibodies e.g., effector functions, as well as anti-drug antibody assays. This position is laboratory-based and will require routine interaction with senior scientists across multiple discovery and core research laboratories at Elanco. The incumbent scientist will be expected to support multiple projects at any given time. The Research Scientist will be responsible for identifying and applying new technologies and innovations to update the capabilities of the research laboratory. A strong foundation in molecular biology, protein biochemistry, and/or cellular biology will be required to proactively search for solutions in this discovery driven team.

Functions, Duties, Task:
  • Conceptualize, design, construct, and validate cell-based bioassays to screen activity and potency of biotherapeutic and vaccine molecules.
  • Conceptualize, design, construct, and validate cell-based bioassays to analyze and monitor effector functions of native and engineered veterinary antibodies.
  • Conceptualize, design, construct, and validate in vitro assays (e.g., BLI, ECL) to evaluate binding kinetics and/or potency of biopharmaceuticals or vaccine antigens for their ligand.
  • Conceptualize, design, construct, and validate cell-based and in vitro anti-drug antibody assays.
  • Keep abreast of scientific literature in the field and implement novel modalities and protocols.
  • Provide expertise in evaluation of new platform technologies.
  • Proactively search for novel technologies or product opportunities and establish collaborations and research programs to deliver innovative technical solutions.
  • Transfer knowledge and information from research to development, from development to registration, and from registration to launch, including the preparation of internal and/or external publications.


49190BR

Basic Qualifications
  • Ph.D. degree in a relevant scientific discipline (molecular biology, microbiology, analytical chemistry, cellular biology, or biochemistry) OR M.S. degree with 10+ years of experience in assay development (diagnostic, clinical, analytical, etc.)


Additional Skills/Preferences
  • Effective oral and written communications skills.
  • High personal ethical and quality standards.
  • Exceptional problem solving and decision-making skills.
  • Must be able to work productively in an interdisciplinary team environment
  • Proven project leadership skills
  • At least 4 years of experience working on R&D projects in the human or animal health industries
  • Practical knowledge and experience in monoclonal antibody assay development
  • Experience in generation/validation of cell-based reporter assays


Additional Information
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.