Senior Scientist I / Scientist II, Chemistry

South San Francisco, CA, US
May 09, 2019
Required Education
Bachelors Degree
Position Type
Full time
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica®, Venclexta™, and Empliciti™ and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.

AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. AbbVie is also expanding their expertise through partnering with companies leading the way in emerging biologic technologies including oncolytic virus' and CAR-T cells. This position is based at AbbVie in the South San Francisco location.

The successful candidate will participate in discovery synthetic chemistry efforts aimed at identifying and developing novel linker/payload technologies for preclinical evaluation and clinical use.

Key Responsibilities Include:
  • Synthesize, purify and characterize biologically-active organic small molecules and linkers;
  • contribute to optimization and validation of synthetic routes applicable for synthesis of linker-drugs on multigram scale;
  • maintain excellent experimental records for research and development efforts;
  • contribute to development and optimization of analytical characterization methods
  • The successful candidate will have strong synthetic skills, outstanding attention to detail and excellent record keeping abilities.

Scientist II: BS or MS in synthetic organic chemistry or equivalent education with typically 7 or more years of experience (BS) or 5 or more years of experience (MS).

Senior Scientist I: BS or MS in synthetic organic chemistry and typically 10 years of experience (BS) or 8 years of experience (MS), or PhD and typically 0-4 years of experience.
  • Experience in multistep organic synthesis
  • Strong small molecule purification skills
  • Knowledge of common spectroscopic and analytical techniques (NMR, LCMS, HPLC)
  • Highly organized and disciplined record keeping
  • Strong attention to detail
  • Strong verbal and written communication skills are essential
  • Excellent laboratory practices and safety techniques are essential
  • Ability to multitask and meet deadlines in a fast-paced environment