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Scientist, Antibody Generation (30)

Employer
Bristol Myers Squibb Company
Location
Redwood City, CA, United States
Start date
May 8, 2019

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Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

Summary

We are seeking a Scientist with hands-on experience in antibody discovery using hybridoma and/or B-cell approaches to support therapeutic biologics programs and reagent antibody generation. Responsibilities will include designing and executing on immunization and screening strategies to generate panels of antibodies that meet the required criteria as well as diverse panels of antibody sequences and epitopes where needed. The candidate must have in-depth knowledge of current state-of-the art antibody generation technologies and be able to apply this to practice at the bench. In depth understanding of immunology, cell biology, and molecular biology is needed as well as a thorough understanding of approaches to manipulate immune response and characterize antibodies (both binding assays and sequence analysis).

Responsibilities
  • Design and execute on antibody discovery goals utilizing hybridoma and molecular biology approaches.
  • Design and execute on approaches to target immune responses to the antigens and epitopes of interest and collaborate with project teams, protein engineering, and HTS and Automation groups for immunogen design and efficient antibody screening cascades.
  • Utilize multiple in-house platforms as needed to meet program requirements, guide project teams towards appropriate technologies or platforms as needed.
  • Integrate data from multiple sources (binding, epitope, sequences, and protein characterization) to generate a complete data package for antibody hit/lead selection
  • Responsible for delivering both data analysis packages as well as purified antibodies to project teams
  • Maintain detailed records of all experiments in ELN and using in-house databases and tracking systems.
  • Communicate with project teams and other stakeholders to ensure that antibody programs are executed efficiently.
  • Trouble-shoot and optimize protocols and propose creative solutions to improve efficiency to existing processes.
  • Proactively evaluate new technologies, instrumentation, and assays available from the literature or scientific meetings to improve in-house platforms.


Qualifications
  • Ph.D. and postdoctoral in Molecular and Cell Biology, Immunology or related field, or advanced degree with 5+ years of relevant experience.
  • Demonstrated experience successfully executing antibody generation using hybridoma approaches and/or B-cell approaches to identify antibody panels is required.
  • Extensive experience with antibody binding assays and analysis, especially ELISA, biosensor, and multi-color flow cytometry is required.
  • Experience with PCR, molecular cloning, and transfection of mammalian cells.
  • Strong experience in Excel, Graphpad Prism, flow cytometry analysis software is required. Familiarity with DNA analysis applications (Vector NTI, Geneious) for antibody sequences is a plus.
  • Strong focus, motivation, and commitment to hands-on lab work is required.
  • Excellent organization and communication skills.
  • Ability to multi-task in a fast-paced environment.
  • Ability to work and thrive in a collaborative, cross-functional team-oriented.

Company

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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Company info
Website
Phone
+1-800-332-2056
Location
430 E. 29th St
14th Floor
New York
New York
10016
United States

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