Research Associate II, Cancer Biology

Location
Bothell, WA, United States
Posted
Apr 30, 2019
Ref
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Required Education
Associate Degree
Position Type
Full time
Summary:

Seattle Genetics is a biotechnology company focused on developing and commercializing innovative, empowered antibody-based therapies for the treatment of cancer. We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells.

We are seeking a talented and highly motivated research associate with a background in cancer biology to join the Cell Biology team. The successful candidate will be involved in cross-functional research activities to validate new oncology targets and design novel antibody-based and small molecule therapeutics for the advancement of SeaGen's drug development pipeline.

Responsibilities:
  • Conduct research to validate novel oncology drug targets
  • Evaluate the antitumor activities and explore mechanism(s) of action of antibodies, ADCs, and small molecule therapeutics
  • Generate and characterize monoclonal antibodies and screen small molecule payloads for novel ADC therapeutic development
  • Support in vivo mechanism of action studies by conducting ex vivo analysis (e.g., immunogenic cell death, bystander effect, signal transduction studies)
  • Produce engineered isogenic cell lines for use in development of cell-based activity assays, binding & specificity studies, and xenograft or syngeneic animal model development
  • Contribute to the maintenance of the mammalian cell line bank for the Research Department
  • Maintain meticulous electronic laboratory notebook entries of research and prepare written technical reports
  • Present experimental results at both internal group meetings and meetings with members of the Research & Translational Sciences departments


Requirements:
  • B.A./B.S. in Cancer Biology, Cell or Developmental Biology, Biochemistry, or related fields in cancer research. Ideal candidate will have 2+ years of biotechnology or pharmaceutical industry experience in cancer drug discovery
  • Experience in cell-based drug activity assays (cell viability, cell death, receptor binding, signal transduction) is required
  • Mammalian cell culture techniques and experience is required
  • Working knowledge of multi-color flow cytometry, ELISA, western blotting, immunofluorescence, qPCR and other molecular and cell-based assays to measure tumor antigen expression and the activities of anti-cancer drugs
  • Utilization of lentiviral and CRISPR/Cas9 gene editing methodologies to generate isogenic cell lines for use in cell-based assays and xenograft or syngeneic animal model development
  • Ability to utilize electronic data capture/analysis tools such as Excel, GraphPad Prism, and PowerPoint for experimental documentation and data analysis/presentations
  • Some experience with small molecule specificity and potency assays is preferred
  • Excellent skills in written and oral communication, organization and multi-tasking, and working in a collaborative and cross-functional research environment
  • Position requires laboratory work, which includes extended periods of sitting and standing


As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.

Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.