Pharmacyclics, LLC

Principal Scientist, Biology Drug Discovery

Sunnyvale, CA, United States
Apr 19, 2019
Biotech Bay
Required Education
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

To learn more about us, please visit us at

General Position Summary/Purpose:

Principal Scientist in research biology with a strong expertise in cancer biology and a proven track record of accomplishments directing disease biology research and drug discovery projects. This position is responsible for providing strong scientific, drug discovery and research team leadership to drive novel target discovery, small molecule drug development, and mechanism-of-action research in the field of hematological malignancies. This position will require ~25% time at the bench.

Key Accountabilities/Core Job Responsibilities:

  • Propose and validate novel therapeutic targets by combining deep understanding of mechanistic biology in hematological malignancies with human genetics and pathology.
  • Conceive, communicate and execute novel multi-disciplinary research strategies that encompass target validation, small molecule drug discovery as biomarker identification.
  • Develop and implement relevant cell-based assays to support SAR activities during hit identification and hit-to-lead optimization.
  • Effectively direct a group of discovery scientists in generating innovative technical and new target strategies that lead to the discovery of novel oncology therapeutic agents.
  • Represent the department on a cross-functional teams (medicinal chemistry, DMPK, pharmacology, safety/toxicology etc.) and effectively collaborate to drive early projects and ensure execution of a robust screening funnel.
  • Actively participate in internal and external scientific meetings by presenting and critically evaluating the science and contributing to projects.
  • Prioritize tasks and contribute to a highly motivated and productive research department with a sense of urgency and desire to meet project timelines.


  • PhD in molecular/cell biology, cancer biology, or related discipline; >8 years industry experience in small molecule oncology drug discovery with prior group management.
  • Broad training in cancer biology, with a focus on hematological malignancies, and a deep understanding of mechanistic cancer biology and current trends in oncology therapeutics.
  • Strong hands-on technical skills in lymphoma/leukemia research. Experience with primary cell culture/co-culture systems desired.
  • Experience in small molecule oncology drug discovery, from target discovery/validation through IND filing is required.
  • Ability to multitask and work within timelines.
  • Effective written and verbal communication skills.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled