Pharmacyclics, LLC

DMPK Research (PK) Focus Intern

Sunnyvale, CA, United States
Apr 19, 2019
Biotech Bay
Required Education
Masters Degree/MBA
Position Type
Full time
Pharmacyclics is committed to the development and commercialization of novel therapies intended to improve the quality and duration of life and to resolve serious unmet medical needs for cancer patients. Pharmacyclics is a wholly-owned subsidiary of AbbVie (NYSE:ABBV), a global, research-based biopharmaceutical company. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products and a pipeline containing multiple promising new molecules that are being studied in more than 200 clinical trials for over 20 different types of cancer.

More than 1,200 Pharmacyclics and AbbVie research scientists, clinicians, marketing, operations and corporate professionals work in the San Francisco Bay Area. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent inhibitor technologies to discover and develop novel cancer treatments. Together, we are striving to outsmart cancer.

Job Description

This individual will be part of drug discovery/ drug metabolism and pharmacokinetics group focusing on the data mining to understand the PK properties of potential new drug molecules.

General Position Summary/Purpose:

· Work closely with an experienced DMPK team representative on a research project
  • Will learn the fundamental of in vivo PK studies, including preparation of study protocols, data analysis and data uploading.
  • Utilize Microsoft office excel to improve our current study protocol preparation, data analysis and reporting workflow
  • Will be exposed to numerous pre-clinical DMPK assays

· Learn QC, and upload data generated by in vivo PK group into database

Value to Pharmacyclics:

· Develop an Excel program to improve our PK study protocol preparation, bioanalytical data summary, PK data analysis and data uploading workflow.

· Develop a database to capture all in vivo PK and PK/PD studies together with preclinical data.

Value to the Intern:

· Learn basic pharmacokinetic principles and parameters

· Become familiar with Phoenix WinNonlin (PK analysis software)

· Gain marketable exposure and skill set in the pharmaceutical industry

Qualifications (Knowledge / Skills / Abilities):

· Currently enrolled in M.S or Ph.D. program in bioinformatics, computer science, or related field

· Candidates must have working knowledge of Microsoft excel and be able to work independently with Microsoft excel.

· Excellent academic achievement and analytical ability

Education Requirements:

· Sophomore or higher that is a current college student or recent college graduate who is studying/has studied coursework in biology, and computer science

· Enrolled in an accredited US University/School

· Prefer candidate that is working towards or earning a basic science degree

· Familiarity with Microsoft Office (especially Excel and PowerPoint)

· Ability communicate well with others

Final Presentation

Each Intern is expected to prepare a short presentation to their team to share what they have learned through their internship and how they hope their new knowledge will be applied to their future. Presentations should be 5-10 minutes long and should include visual aid (posters or PowerPoint).

Equal Opportunity Employer Minorities/Women/Veterans/Disabled